ENZYME entry: EC 2.4.2.21

Accepted Name
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase.
Alternative Name(s)
N(1)-alpha-phosphoribosyltransferase.
Nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase.
Reaction catalysed
Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole <=> nicotinate + alpha-ribazole 5'-phosphate
Comment(s)
  • Also acts on benzimidazole, and the clostridial enzyme acts on adenine to form 7-alpha-D-ribosyladenine 5'-phosphate.
  • The product of the reaction, alpha-ribazole 5'-phosphate, forms part of the corrin biosynthesis pathway and is a substrate for EC 2.7.8.2.
  • It can also be dephosphorylated to form alpha-ribazole by the action of EC 3.1.3.73.
Cross-references
BRENDA2.4.2.21
EC2PDB2.4.2.21
ExplorEnz2.4.2.21
PRIAM enzyme-specific profiles2.4.2.21
KEGG Ligand Database for Enzyme Nomenclature2.4.2.21
IUBMB Enzyme Nomenclature2.4.2.21
IntEnz2.4.2.21
MEDLINEFind literature relating to 2.4.2.21
MetaCyc2.4.2.21
UniProtKB/Swiss-Prot
B9JG15, COBT_AGRRK;  Q8UE71, COBT_AGRT5;  B9JW09, COBT_AGRVS;  
A6TKH4, COBT_ALKMQ;  Q5P2R4, COBT_AROAE;  A1KBH0, COBT_AZOSB;  
C1DPN9, COBT_AZOVD;  Q5LCE6, COBT_BACFN;  Q64TE4, COBT_BACFR;  
Q9KG31, COBT_BACHD;  A6L518, COBT_BACV8;  Q89Q54, COBT_BRADU;  
A5EGF4, COBT_BRASB;  A4YXK4, COBT_BRASO;  B2S5A1, COBT_BRUA1;  
Q2YNK7, COBT_BRUA2;  Q57DN9, COBT_BRUAB;  A9MAP0, COBT_BRUC2;  
C0RIK0, COBT_BRUMB;  Q8YGQ9, COBT_BRUME;  B0CLJ2, COBT_BRUSI;  
Q8G155, COBT_BRUSU;  A9WIQ7, COBT_CHLAA;  B8G806, COBT_CHLAD;  
Q3ARQ5, COBT_CHLCH;  B3QNS6, COBT_CHLP8;  A1BF69, COBT_CHLPD;  
B9LKQ0, COBT_CHLSY;  Q8KDU8, COBT_CHLTE;  Q7P0S3, COBT_CHRVO;  
Q97JB4, COBT_CLOAB;  B8I7A3, COBT_CLOCE;  Q0TRK5, COBT_CLOP1;  
Q8XLK7, COBT_CLOPE;  Q891S7, COBT_CLOTE;  A3DF00, COBT_CLOTH;  
Q8FNQ2, COBT_COREF;  A4QFR5, COBT_CORGB;  Q8NNJ8, COBT_CORGL;  
Q0K7H7, COBT_CUPNH;  B3R647, COBT_CUPTR;  Q47JS4, COBT_DECAR;  
A5FRG9, COBT_DEHMB;  Q3ZX54, COBT_DEHMC;  Q9RYR8, COBT_DEIRA;  
Q30US7, COBT_DESAG;  B1I4H2, COBT_DESAP;  C4XMZ1, COBT_DESMR;  
Q6ALU4, COBT_DESPS;  A4J829, COBT_DESRM;  Q725Z4, COBT_DESVH;  
A1V9L9, COBT_DESVV;  A7ZNF5, COBT_ECO24;  B7UT20, COBT_ECO27;  
B7MDB7, COBT_ECO45;  B7L916, COBT_ECO55;  Q8X8V0, COBT_ECO57;  
B5YSS0, COBT_ECO5E;  B7NR83, COBT_ECO7I;  B7MWP8, COBT_ECO81;  
B7M3C7, COBT_ECO8A;  C4ZQQ4, COBT_ECOBW;  B1X6S9, COBT_ECODH;  
A8A1K5, COBT_ECOHS;  A1ACI8, COBT_ECOK1;  Q0TGE1, COBT_ECOL5;  
Q8FGA5, COBT_ECOL6;  B1IZQ9, COBT_ECOLC;  P36562, COBT_ECOLI;  
B7NC25, COBT_ECOLU;  B6I828, COBT_ECOSE;  B1LPV7, COBT_ECOSM;  
Q1RAB7, COBT_ECOUT;  Q8RF14, COBT_FUSNN;  B5EEL9, COBT_GEOBB;  
B9LZU2, COBT_GEODF;  Q39YG4, COBT_GEOMG;  Q748J3, COBT_GEOSL;  
C6E7Q4, COBT_GEOSM;  A5G962, COBT_GEOUR;  A9B732, COBT_HERA2;  
A6SWY0, COBT_JANMA;  Q28M40, COBT_JANSC;  Q04PD9, COBT_LEPBJ;  
Q055Y6, COBT_LEPBL;  Q72M35, COBT_LEPIC;  Q8EYK9, COBT_LEPIN;  
Q9X7F4, COBT_METC4;  B8ERB9, COBT_METSB;  A0QEZ9, COBT_MYCA1;  
P63842, COBT_MYCBO;  A1KKP9, COBT_MYCBP;  C1AQC2, COBT_MYCBT;  
B8ZQK8, COBT_MYCLB;  O32953, COBT_MYCLE;  B2HGX6, COBT_MYCMM;  
Q73YK7, COBT_MYCPA;  A5U4N5, COBT_MYCTA;  P9WP84, COBT_MYCTO;  
P9WP85, COBT_MYCTU;  A0PTP2, COBT_MYCUA;  Q2GBJ7, COBT_NOVAD;  
A6X1H0, COBT_OCHA4;  A6LIW6, COBT_PARD8;  Q3A798, COBT_PELCD;  
B4SH92, COBT_PELPB;  Q180T6, COBT_PEPD6;  Q7N2U4, COBT_PHOLL;  
Q6LSY3, COBT_PHOPR;  B2RIR0, COBT_PORG3;  Q7MWC6, COBT_PORGI;  
B4S893, COBT_PROA2;  A4SEC8, COBT_PROVI;  Q48FJ9, COBT_PSE14;  
B7UWH1, COBT_PSEA8;  Q02JC0, COBT_PSEAB;  Q9I465, COBT_PSEAE;  
Q1IDJ7, COBT_PSEE4;  Q4K8C1, COBT_PSEF5;  C3K0Y8, COBT_PSEFS;  
Q3IK32, COBT_PSEHT;  A4XT55, COBT_PSEMY;  A5W7Q4, COBT_PSEP1;  
Q3KFR5, COBT_PSEPF;  B0KT67, COBT_PSEPG;  Q88M95, COBT_PSEPK;  
B1J1N8, COBT_PSEPW;  Q885W6, COBT_PSESM;  Q4ZQ66, COBT_PSEU2;  
Q8XWS3, COBT_RALSO;  B3PQS3, COBT_RHIE6;  Q2K7G6, COBT_RHIEC;  
Q1MFK4, COBT_RHIL3;  Q98KN9, COBT_RHILO;  B5ZSC4, COBT_RHILW;  
Q92P98, COBT_RHIME;  C3MDH9, COBT_RHISN;  P0CY58, COBT_RHOCA;  
D5AV20, COBT_RHOCB;  A3PIN5, COBT_RHOS1;  Q3J3P6, COBT_RHOS4;  
A4WRE3, COBT_RHOS5;  B9KQ95, COBT_RHOSK;  A7NH25, COBT_ROSCS;  
Q169A0, COBT_ROSDO;  A5UQS8, COBT_ROSS1;  Q5LTJ1, COBT_RUEPO;  
Q1GJ55, COBT_RUEST;  B5EWY2, COBT_SALA4;  A9MLS8, COBT_SALAR;  
B5FLY4, COBT_SALDC;  B5QYX3, COBT_SALEP;  B5RBK6, COBT_SALG2;  
B4T8W8, COBT_SALHS;  B4SWC5, COBT_SALNS;  Q5PDU9, COBT_SALPA;  
A9MTA4, COBT_SALPB;  C0Q1R0, COBT_SALPC;  B5BG60, COBT_SALPK;  
B4TZP5, COBT_SALSV;  Q8Z5N9, COBT_SALTI;  A4XAM8, COBT_SALTO;  
Q05603, COBT_SALTY;  A1S3L3, COBT_SHEAM;  B8E4M8, COBT_SHEB2;  
A3D7X8, COBT_SHEB5;  A6WJZ1, COBT_SHEB8;  A9L3D8, COBT_SHEB9;  
Q086T6, COBT_SHEFN;  B0TT63, COBT_SHEHH;  A3QAT8, COBT_SHELP;  
Q8EI18, COBT_SHEON;  A4Y9P3, COBT_SHEPC;  B8CJ37, COBT_SHEPW;  
A0L0D3, COBT_SHESA;  A8FZR5, COBT_SHESH;  Q0HLZ5, COBT_SHESM;  
Q0HRU1, COBT_SHESR;  A1RGP1, COBT_SHESW;  B2TWR0, COBT_SHIB3;  
Q32ED0, COBT_SHIDS;  Q0T3C4, COBT_SHIF8;  Q83R14, COBT_SHIFL;  
Q3Z0K4, COBT_SHISS;  A6U9W4, COBT_SINMW;  Q82AM7, COBT_STRAW;  
Q9S2R1, COBT_STRCO;  A0LF21, COBT_SYNFM;  Q7SIC7, COBT_THET8;  
C5CKN8, COBT_VARPS;  A7MVW6, COBT_VIBCB;  Q9KSL9, COBT_VIBCH;  
Q87Q46, COBT_VIBPA;  B7VPD7, COBT_VIBTL;  Q8D921, COBT_VIBVU;  
Q7MLF3, COBT_VIBVY;  Q8PHR3, COBT_XANAC;  Q3BQB7, COBT_XANC5;  
Q4UXQ4, COBT_XANC8;  B0RPU9, COBT_XANCB;  Q8P6B1, COBT_XANCP;  
Q2P631, COBT_XANOM;  B2SJ67, COBT_XANOP;  A1JTP8, COBT_YERE8;  
P29935, COBU_PSEDE;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-