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ENZYME entry: EC 2.4.2.29

Accepted Name
tRNA-guanine(34) transglycosylase.
Alternative Name(s)
Guanine insertion enzyme.
Q-insertase.
Queuine tRNA-ribosyltransferase.
Queuine(34) transfer ribonucleate ribosyltransferase.
TGT.
tRNA guanine(34) transglycosidase.
tRNA transglycosylase.
Reaction catalysed
  • Guanine(34) in tRNA + queuine <=> queuosine(34) in tRNA + guanine
  • Guanine(34) in tRNA + 7-aminomethyl-7-carbaguanine <=> 7-aminomethyl-7-carbaguanine(34) in tRNA + guanine
Comment(s)
  • Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34.
  • In eukaryotes queuine is salvaged from food and incorporated into tRNA directly via a base-exchange reaction, replacing guanine.
  • In eubacteria, which produce queuine de novo, the enzyme catalyzes the exchange of guanine with the queuine precursor preQ(1), which is ultimately modified to queuine.
  • The eubacterial enzyme can also use an earlier intermediate, preQ(0), to replace guanine in unmodified tRNA(Tyr) and tRNA(Asn).
  • This enzyme acts after EC 1.7.1.13 in the queuine-biosynthesis pathway.
Cross-references
BRENDA2.4.2.29
EC2PDB2.4.2.29
ExplorEnz2.4.2.29
PRIAM enzyme-specific profiles2.4.2.29
KEGG Ligand Database for Enzyme Nomenclature2.4.2.29
IUBMB Enzyme Nomenclature2.4.2.29
IntEnz2.4.2.29
MEDLINEFind literature relating to 2.4.2.29
MetaCyc2.4.2.29
UniProtKB/Swiss-Prot
A1TVN0, TGT_ACIAC;  Q6FEJ4, TGT_ACIAD;  B7GWL4, TGT_ACIB3;  
B7I976, TGT_ACIB5;  B2HYN7, TGT_ACIBC;  B0VRA8, TGT_ACIBS;  
A3M8S3, TGT_ACIBT;  B0V625, TGT_ACIBY;  B9MGI1, TGT_ACIET;  
B7J4R9, TGT_ACIF2;  B5EK08, TGT_ACIF5;  A1WCK2, TGT_ACISJ;  
A3N087, TGT_ACTP2;  B3GXF8, TGT_ACTP7;  B0BP03, TGT_ACTPJ;  
A6VN75, TGT_ACTSZ;  A0KJ20, TGT_AERHH;  A4SP26, TGT_AERS4;  
Q8UES8, TGT_AGRFC;  B6EK65, TGT_ALISL;  B7GFN1, TGT_ANOFW;  
O67331, TGT_AQUAE;  A8ERD1, TGT_ARCB4;  O28787, TGT_ARCFU;  
Q5P720, TGT_AROAE;  A1K3W9, TGT_AZOSB;  C1DE76, TGT_AZOVD;  
C3P9A4, TGT_BACAA;  C3L6U6, TGT_BACAC;  A0RJ24, TGT_BACAH;  
Q81LH2, TGT_BACAN;  B7JQ03, TGT_BACC0;  Q730B4, TGT_BACC1;  
B7IIS9, TGT_BACC2;  C1ESW1, TGT_BACC3;  B7HE51, TGT_BACC4;  
B7HQH6, TGT_BACC7;  A7GT99, TGT_BACCN;  B9IYZ1, TGT_BACCQ;  
Q817W6, TGT_BACCR;  Q634C7, TGT_BACCZ;  Q9KDI5, TGT_BACHD;  
Q6HDA9, TGT_BACHK;  Q65GP9, TGT_BACLD;  A8FFQ9, TGT_BACP2;  
Q5WHR2, TGT_BACSK;  O32053, TGT_BACSU;  A7Z766, TGT_BACVZ;  
A9VIP3, TGT_BACWK;  Q1LSP0, TGT_BAUCH;  Q7VQB1, TGT_BLOFL;  
Q493H3, TGT_BLOPB;  Q65ZW4, TGT_BORBP;  O51749, TGT_BORBU;  
B7J0Q4, TGT_BORBZ;  B5RN03, TGT_BORDL;  B2S1F3, TGT_BORHD;  
B5RQE7, TGT_BORRA;  A1R0N4, TGT_BORT9;  C0R0X6, TGT_BRAHW;  
Q8YHB2, TGT_BRUME;  Q8G0K1, TGT_BRUSU;  B8D8T4, TGT_BUCA5;  
P57233, TGT_BUCAI;  Q8KA09, TGT_BUCAP;  B8D738, TGT_BUCAT;  
A8X0P0, TGT_CAEBR;  Q23623, TGT_CAEEL;  Q8RAM9, TGT_CALS4;  
A7ZD89, TGT_CAMC1;  A7GYD5, TGT_CAMC5;  A0RPL5, TGT_CAMFF;  
A7I2I6, TGT_CAMHC;  A8FM59, TGT_CAMJ8;  A7H331, TGT_CAMJD;  
Q9PNT0, TGT_CAMJE;  A1VZZ8, TGT_CAMJJ;  Q5HUF2, TGT_CAMJR;  
B9KFT3, TGT_CAMLR;  Q9A7Y1, TGT_CAUCR;  Q5L5T1, TGT_CHLAB;  
Q822U8, TGT_CHLCV;  Q254U7, TGT_CHLFF;  Q9PKK0, TGT_CHLMU;  
Q9Z8W5, TGT_CHLPN;  B0B9U3, TGT_CHLT2;  Q3KMG9, TGT_CHLTA;  
B0BBH3, TGT_CHLTB;  O84196, TGT_CHLTR;  Q1QTM9, TGT_CHRSD;  
Q7NYC7, TGT_CHRVO;  A8AK48, TGT_CITK8;  Q97GT3, TGT_CLOAB;  
A7FY17, TGT_CLOB1;  C3KTD0, TGT_CLOB6;  A5I6E9, TGT_CLOBH;  
C1FKF9, TGT_CLOBJ;  B1IMF1, TGT_CLOBK;  A7GHT6, TGT_CLOBL;  
B1L0B0, TGT_CLOBM;  B8I6M0, TGT_CLOCE;  B9E5Q6, TGT_CLOK1;  
A5N204, TGT_CLOK5;  Q0TP15, TGT_CLOP1;  Q8XJ16, TGT_CLOPE;  
Q0SRN5, TGT_CLOPS;  Q892A0, TGT_CLOTE;  A3DE13, TGT_CLOTH;  
Q1LJ59, TGT_CUPMC;  Q0K733, TGT_CUPNH;  Q46XG4, TGT_CUPNJ;  
B3R6J4, TGT_CUPTR;  B8HX02, TGT_CYAP4;  Q7SYK1, TGT_DANRE;  
Q47AX3, TGT_DECAR;  Q3ZAE2, TGT_DEHM1;  A5FSU3, TGT_DEHMB;  
Q3ZWC1, TGT_DEHMC;  Q9RRB5, TGT_DEIRA;  A9BRD7, TGT_DELAS;  
Q30XF7, TGT_DESAG;  C0QKY2, TGT_DESAH;  B1I4K8, TGT_DESAP;  
B8FQV2, TGT_DESHD;  C4XSI9, TGT_DESMR;  A8ZRX7, TGT_DESOH;  
A4J541, TGT_DESRM;  Q72E53, TGT_DESVH;  A1VFP3, TGT_DESVV;  
A5EW66, TGT_DICNV;  B5YFK5, TGT_DICT6;  B8E2N5, TGT_DICTD;  
A8LRQ1, TGT_DINSH;  Q9VPY8, TGT_DROME;  A7ZIF8, TGT_ECO24;  
B7UJM9, TGT_ECO27;  B7MD64, TGT_ECO45;  B7L639, TGT_ECO55;  
P0A849, TGT_ECO57;  B5Z2W2, TGT_ECO5E;  B7NJ96, TGT_ECO7I;  
B7MPG7, TGT_ECO81;  B7M3P5, TGT_ECO8A;  C4ZTG3, TGT_ECOBW;  
B1XEZ4, TGT_ECODH;  A7ZX57, TGT_ECOHS;  A1A876, TGT_ECOK1;  
Q0TKN5, TGT_ECOL5;  P0A848, TGT_ECOL6;  B1J043, TGT_ECOLC;  
P0A847, TGT_ECOLI;  B7N8V8, TGT_ECOLU;  B6HZK6, TGT_ECOSE;  
B1LJF4, TGT_ECOSM;  Q1RFD5, TGT_ECOUT;  C5BCF7, TGT_EDWI9;  
A4W779, TGT_ENT38;  Q837E7, TGT_ENTFA;  B2VHQ1, TGT_ERWT9;  
B7LMI1, TGT_ESCF3;  C4Z563, TGT_EUBE2;  B0TYY3, TGT_FRAP2;  
Q14HA0, TGT_FRAT1;  A7NBL6, TGT_FRATF;  Q2A3Y7, TGT_FRATH;  
B2SHD4, TGT_FRATM;  A0Q6X1, TGT_FRATN;  Q0BMC7, TGT_FRATO;  
Q5NFU8, TGT_FRATT;  A4IYF8, TGT_FRATW;  Q8RDN0, TGT_FUSNN;  
Q5KWR4, TGT_GEOKA;  A4IRA9, TGT_GEOTN;  Q7NMG4, TGT_GLOVI;  
A9HBJ2, TGT_GLUDA;  Q0BVG4, TGT_GRABC;  Q7VLQ4, TGT_HAEDU;  
Q4QNU3, TGT_HAEI8;  A5UAP3, TGT_HAEIE;  A5UG47, TGT_HAEIG;  
P44594, TGT_HAEIN;  B8F3W0, TGT_HAEPS;  Q0I4R8, TGT_HAES1;  
B8CXG0, TGT_HALOH;  C4K8M3, TGT_HAMD5;  Q17YB5, TGT_HELAH;  
Q7VHX2, TGT_HELHP;  B6JKL0, TGT_HELP2;  B5ZA47, TGT_HELPG;  
Q1CUM2, TGT_HELPH;  Q9ZMF4, TGT_HELPJ;  B2USB2, TGT_HELPS;  
O08314, TGT_HELPY;  A9AW42, TGT_HERA2;  A4G1Z3, TGT_HERAR;  
Q9BXR0, TGT_HUMAN;  Q5QVL2, TGT_IDILO;  A6SUU4, TGT_JANMA;  
Q28PC5, TGT_JANSC;  B5Y0Y6, TGT_KLEP3;  A6T5D8, TGT_KLEP7;  
Q1IVF1, TGT_KORVE;  Q9CJ54, TGT_LACLA;  A2RHN5, TGT_LACLM;  
Q032U4, TGT_LACLS;  A9KHU4, TGT_LACP7;  Q88V05, TGT_LACPL;  
Q38YP9, TGT_LACSS;  C1DDA7, TGT_LARHH;  Q1MPU5, TGT_LAWIP;  
B0SCA8, TGT_LEPBA;  Q04UC6, TGT_LEPBJ;  Q04Z48, TGT_LEPBL;  
B0SKS9, TGT_LEPBP;  B1XWG6, TGT_LEPCP;  Q72TL3, TGT_LEPIC;  
Q8CXS3, TGT_LEPIN;  Q92BI4, TGT_LISIN;  C1KVH7, TGT_LISMC;  
Q71ZE0, TGT_LISMF;  B8DHL8, TGT_LISMH;  Q8Y700, TGT_LISMO;  
A0AIX9, TGT_LISW6;  B1HVA1, TGT_LYSSC;  B9E716, TGT_MACCJ;  
Q65S94, TGT_MANSM;  A1TZN7, TGT_MARHV;  Q1H403, TGT_METFK;  
B3DYE4, TGT_METI4;  A2SM97, TGT_METPP;  Q2RHU3, TGT_MOOTA;  
Q9JMA2, TGT_MOUSE;  B2A5K8, TGT_NATTJ;  B9L8E1, TGT_NAUPA;  
Q5F9U5, TGT_NEIG1;  B4RJY2, TGT_NEIG2;  A9M374, TGT_NEIM0;  
Q9JVA4, TGT_NEIMA;  Q9K096, TGT_NEIMB;  A1KSY1, TGT_NEIMF;  
Q0AG55, TGT_NITEC;  Q82VF0, TGT_NITEU;  Q2Y6A3, TGT_NITMU;  
A6Q3Y5, TGT_NITSB;  Q8YVT9, TGT_NOSS1;  Q2G639, TGT_NOVAD;  
Q8CXC4, TGT_OCEIH;  Q6MD31, TGT_PARUW;  P57831, TGT_PASMU;  
Q6D855, TGT_PECAS;  C6DB26, TGT_PECCP;  Q03ER2, TGT_PEDPA;  
A5D3G6, TGT_PELTS;  Q7MB01, TGT_PHOLL;  Q6LU69, TGT_PHOPR;  
A1VJ15, TGT_POLNA;  Q12GB2, TGT_POLSJ;  A3PAZ2, TGT_PROM0;  
A8G2T1, TGT_PROM2;  A2CCL1, TGT_PROM3;  A9BDP3, TGT_PROM4;  
A2BUQ2, TGT_PROM5;  Q31CR1, TGT_PROM9;  Q7VDR5, TGT_PROMA;  
B4EU13, TGT_PROMH;  Q7TUM6, TGT_PROMM;  Q7TUG0, TGT_PROMP;  
A2BP70, TGT_PROMS;  Q15WI4, TGT_PSEA6;  B7UVU4, TGT_PSEA8;  
Q02RX7, TGT_PSEAB;  Q9HXH9, TGT_PSEAE;  Q3ILB8, TGT_PSEHT;  
Q88PL7, TGT_PSEPK;  Q887B0, TGT_PSESM;  Q4FRI6, TGT_PSYA2;  
Q1QA23, TGT_PSYCK;  A1SWU0, TGT_PSYIN;  A5WGS6, TGT_PSYWF;  
B2UC75, TGT_RALPJ;  Q8XVW4, TGT_RALSO;  Q4QR99, TGT_RAT;  
Q98M57, TGT_RHILO;  Q92PY4, TGT_RHIME;  Q7UWK9, TGT_RHOBA;  
A3PJT9, TGT_RHOS1;  Q3J2H4, TGT_RHOS4;  C3PLJ4, TGT_RICAE;  
A8GPN2, TGT_RICAH;  A8GUA5, TGT_RICB8;  Q1RH25, TGT_RICBR;  
A8EZT7, TGT_RICCK;  Q92GM6, TGT_RICCN;  Q4UN16, TGT_RICFE;  
A8F2K6, TGT_RICM5;  Q9ZCK8, TGT_RICPR;  C4K0T2, TGT_RICPU;  
B0BUZ2, TGT_RICRO;  A8GTF4, TGT_RICRS;  Q68W26, TGT_RICTY;  
A5USV3, TGT_ROSS1;  Q5LQ80, TGT_RUEPO;  Q1GIL3, TGT_RUEST;  
Q21KW1, TGT_SACD2;  B5EWT9, TGT_SALA4;  A9MM57, TGT_SALAR;  
Q57SF8, TGT_SALCH;  B5FKR0, TGT_SALDC;  B5QTF4, TGT_SALEP;  
B5R6Q7, TGT_SALG2;  B4T8P5, TGT_SALHS;  B4SWP7, TGT_SALNS;  
Q5PFT6, TGT_SALPA;  A9MX29, TGT_SALPB;  C0Q7S9, TGT_SALPC;  
B5BDC8, TGT_SALPK;  B4TZI0, TGT_SALSV;  Q8Z8Y0, TGT_SALTI;  
Q8ZRD8, TGT_SALTY;  O94460, TGT_SCHPO;  A8GAM5, TGT_SERP5;  
A1S7P2, TGT_SHEAM;  B8EDJ7, TGT_SHEB2;  A3D6B1, TGT_SHEB5;  
A6WQ52, TGT_SHEB8;  A9KUN0, TGT_SHEB9;  Q12PD9, TGT_SHEDO;  
Q07ZM2, TGT_SHEFN;  B0TND4, TGT_SHEHH;  A3QFF5, TGT_SHELP;  
Q8ECM3, TGT_SHEON;  A8H2K8, TGT_SHEPA;  A4Y8C2, TGT_SHEPC;  
B8CLC5, TGT_SHEPW;  A0KV50, TGT_SHESA;  A8FXC6, TGT_SHESH;  
Q0HKF7, TGT_SHESM;  Q0HWQ9, TGT_SHESR;  A1RI67, TGT_SHESW;  
B2U4K7, TGT_SHIB3;  Q325J5, TGT_SHIBS;  Q32JG0, TGT_SHIDS;  
Q0T7I3, TGT_SHIF8;  Q54177, TGT_SHIFL;  Q3Z503, TGT_SHISS;  
Q2NVA4, TGT_SODGM;  Q029K6, TGT_SOLUE;  A9FI06, TGT_SORC5;  
Q1GR26, TGT_SPHAL;  A7X354, TGT_STAA1;  A6U2A7, TGT_STAA2;  
Q2FG88, TGT_STAA3;  Q2FXT6, TGT_STAA8;  A5ITG3, TGT_STAA9;  
Q2YT91, TGT_STAAB;  Q5HFC4, TGT_STAAC;  A6QHI1, TGT_STAAE;  
P66904, TGT_STAAM;  P66905, TGT_STAAN;  Q6GG65, TGT_STAAR;  
Q6G8T0, TGT_STAAS;  A8Z2G7, TGT_STAAT;  P66906, TGT_STAAW;  
B9DNG7, TGT_STACT;  Q5HNR2, TGT_STAEQ;  Q8CML7, TGT_STAES;  
Q4L6Y4, TGT_STAHJ;  Q3K2Y7, TGT_STRA1;  Q8E6X6, TGT_STRA3;  
Q8E1F9, TGT_STRA5;  C0MAH5, TGT_STRE4;  A8AUL3, TGT_STRGC;  
B4SSS1, TGT_STRM5;  B2FN00, TGT_STRMK;  Q8DVZ3, TGT_STRMU;  
Q9A1L6, TGT_STRP1;  Q04IB3, TGT_STRP2;  P0DF86, TGT_STRP3;  
B5E2X9, TGT_STRP4;  Q5XE18, TGT_STRP6;  C1CAA6, TGT_STRP7;  
P66910, TGT_STRP8;  Q1JDS0, TGT_STRPB;  Q1JNN4, TGT_STRPC;  
Q1JIT0, TGT_STRPD;  Q1J8P1, TGT_STRPF;  A2RCC9, TGT_STRPG;  
B1I9B4, TGT_STRPI;  B8ZPB8, TGT_STRPJ;  Q48VG9, TGT_STRPM;  
P66907, TGT_STRPN;  P0DF87, TGT_STRPQ;  B2IMN3, TGT_STRPS;  
B5XJL3, TGT_STRPZ;  P66908, TGT_STRR6;  A4W2F8, TGT_STRS2;  
C0MEV8, TGT_STRS7;  A3CK60, TGT_STRSV;  A4VW51, TGT_STRSY;  
Q5LY05, TGT_STRT1;  Q5M2K9, TGT_STRT2;  Q03IQ5, TGT_STRTD;  
B9DVZ9, TGT_STRU0;  C1CGY8, TGT_STRZJ;  C1CN05, TGT_STRZP;  
C1CTW4, TGT_STRZT;  Q30S46, TGT_SULDN;  A6Q906, TGT_SULNB;  
Q67Q92, TGT_SYMTH;  Q8GAA6, TGT_SYNE7;  A0LFR2, TGT_SYNFM;  
Q7TTX7, TGT_SYNPX;  Q0IDF3, TGT_SYNS3;  Q3B088, TGT_SYNS9;  
Q3AN18, TGT_SYNSC;  Q55983, TGT_SYNY3;  B7IDU1, TGT_THEAB;  
Q8CWM7, TGT_THEEB;  A6LMW2, TGT_THEM4;  Q9X1P7, TGT_THEMA;  
B9K8N7, TGT_THENN;  A5IM22, TGT_THEP1;  B0K959, TGT_THEP3;  
B0K0M1, TGT_THEPX;  B1LB70, TGT_THESQ;  Q72H19, TGT_THET2;  
Q5SLI7, TGT_THET8;  B5YHX4, TGT_THEYD;  Q31FZ5, TGT_THICR;  
Q3SH61, TGT_THIDA;  B8GTQ4, TGT_THISH;  C4L7L3, TGT_TOLAT;  
Q73QK5, TGT_TREDE;  A1WFH2, TGT_VEREI;  A5CW46, TGT_VESOH;  
A5F3H2, TGT_VIBC3;  A7MT83, TGT_VIBCB;  Q9KTY9, TGT_VIBCH;  
C3LSZ4, TGT_VIBCM;  Q5E3D2, TGT_VIBF1;  B5F9Y3, TGT_VIBFM;  
Q87S36, TGT_VIBPA;  B7VJR8, TGT_VIBTL;  Q8DEY0, TGT_VIBVU;  
Q7MNH1, TGT_VIBVY;  Q7M8N8, TGT_WOLSU;  Q8PJL7, TGT_XANAC;  
Q3BS37, TGT_XANC5;  Q4UVX2, TGT_XANC8;  B0RRR1, TGT_XANCB;  
Q8P868, TGT_XANCP;  Q2P2X0, TGT_XANOM;  B2SIN8, TGT_XANOP;  
Q5GZY3, TGT_XANOR;  Q4QQY7, TGT_XENLA;  Q28HC6, TGT_XENTR;  
B2I6T4, TGT_XYLF2;  Q9PGS5, TGT_XYLFA;  B0U1P6, TGT_XYLFM;  
Q87EW6, TGT_XYLFT;  A1JNT0, TGT_YERE8;  A7FLF5, TGT_YERP3;  
Q1C4H4, TGT_YERPA;  B2K6S6, TGT_YERPB;  Q8ZC33, TGT_YERPE;  
A9R351, TGT_YERPG;  Q1CLA2, TGT_YERPN;  A4TPH6, TGT_YERPP;  
Q66DW5, TGT_YERPS;  B1JIE9, TGT_YERPY;  P28720, TGT_ZYMMO;  

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