ENZYME entry: EC 2.4.2.30

Accepted Name
NAD(+) ADP-ribosyltransferase.
Alternative Name(s)
ADP-ribosyltransferase (polymerizing).
Poly(adenosine diphosphate ribose) polymerase.
Poly(ADP-ribose) synthetase.
Poly(ADP-ribose)polymerase.
Reaction catalysed
NAD(+) + (ADP-D-ribosyl)(n)-acceptor <=> nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Comment(s)
The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
Cross-references
PROSITEPDOC00360 ; PDOC51059
BRENDA2.4.2.30
EC2PDB2.4.2.30
ExplorEnz2.4.2.30
PRIAM enzyme-specific profiles2.4.2.30
KEGG Ligand Database for Enzyme Nomenclature2.4.2.30
IUBMB Enzyme Nomenclature2.4.2.30
IntEnz2.4.2.30
MEDLINEFind literature relating to 2.4.2.30
MetaCyc2.4.2.30
UniProtKB/Swiss-Prot
Q53GL7, PAR10_HUMAN;  Q9NR21, PAR11_HUMAN;  Q8CFF0, PAR11_MOUSE;  
Q9H0J9, PAR12_HUMAN;  Q8BZ20, PAR12_MOUSE;  Q460N5, PAR14_HUMAN;  
Q2EMV9, PAR14_MOUSE;  Q460N3, PAR15_HUMAN;  Q5U2Q4, PAR16_RAT;  
Q9ZP54, PARP1_ARATH;  P18493, PARP1_BOVIN;  P26446, PARP1_CHICK;  
Q9R152, PARP1_CRIGR;  P09874, PARP1_HUMAN;  Q9ZSV1, PARP1_MAIZE;  
P11103, PARP1_MOUSE;  Q08824, PARP1_ONCMA;  Q7EYV7, PARP1_ORYSJ;  
P27008, PARP1_RAT;  P31669, PARP1_XENLA;  Q11207, PARP2_ARATH;  
Q9UGN5, PARP2_HUMAN;  O50017, PARP2_MAIZE;  O88554, PARP2_MOUSE;  
Q9FK91, PARP3_ARATH;  Q9Y6F1, PARP3_HUMAN;  Q1SGF1, PARP3_MEDTR;  
Q0E0Q3, PARP3_ORYSJ;  Q9SWB4, PARP3_SOYBN;  Q9UKK3, PARP4_HUMAN;  
Q2NL67, PARP6_HUMAN;  Q6P6P7, PARP6_MOUSE;  Q5RDU4, PARP6_PONAB;  
Q8N3A8, PARP8_HUMAN;  Q3UD82, PARP8_MOUSE;  Q8IXQ6, PARP9_HUMAN;  
Q8CAS9, PARP9_MOUSE;  Q7Z3E1, PARPT_HUMAN;  Q8C1B2, PARPT_MOUSE;  
P35875, PARP_DROME;  O55721, PARP_IIV6;  Q11208, PARP_SARPE;  
B3EWG9, PARP_SULSF;  Q9N4H4, PME1_CAEEL;  Q09525, PME2_CAEEL;  
Q9TXQ1, PME5_CAEEL;  Q5Z8Q9, PRP2A_ORYSJ;  Q0JMY1, PRP2B_ORYSJ;  
O95271, TNKS1_HUMAN;  Q6PFX9, TNKS1_MOUSE;  Q9H2K2, TNKS2_HUMAN;  
Q3UES3, TNKS2_MOUSE;  Q9VBP3, TNKS_DROME;  Q54YW4, Y8045_DICDI;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
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