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ENZYME

ENZYME entry: EC 2.4.2.30

Accepted Name
NAD(+) ADP-ribosyltransferase
Alternative Name(s)
ADP-ribosyltransferase (polymerizing)
poly(adenosine diphosphate ribose) polymerase
poly(ADP-ribose)polymerase
poly(ADP-ribose) synthetase
Reaction catalysed
NAD(+) + (ADP-D-ribosyl)n-acceptor <=> nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+)
Comment(s)
The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
Cross-references
BRENDA2.4.2.30
EC2PDB2.4.2.30
ExplorEnz2.4.2.30
PRIAM enzyme-specific profiles2.4.2.30
KEGG Ligand Database for Enzyme Nomenclature2.4.2.30
IUBMB Enzyme Nomenclature2.4.2.30
IntEnz2.4.2.30
MEDLINEFind literature relating to 2.4.2.30
MetaCyc2.4.2.30
Rhea expert-curated reactions2.4.2.30
UniProtKB/Swiss-Prot
Q9ZP54, PARP1_ARATHP18493, PARP1_BOVINQ9N4H4, PARP1_CAEEL
P26446, PARP1_CHICKQ9R152, PARP1_CRIGRQ5RHR0, PARP1_DANRE
P09874, PARP1_HUMANQ9ZSV1, PARP1_MAIZEP11103, PARP1_MOUSE
Q08824, PARP1_ONCMAQ7EYV7, PARP1_ORYSJP27008, PARP1_RAT
P31669, PARP1_XENLAQ11207, PARP2_ARATHQ09525, PARP2_CAEEL
Q9UGN5, PARP2_HUMANO50017, PARP2_MAIZEO88554, PARP2_MOUSE
P35875, PARP_DROMEO55721, PARP_IIV6B3EWG9, PARP_SACSO
Q11208, PARP_SARPEQ5Z8Q9, PRP2A_ORYSJQ0JMY1, PRP2B_ORYSJ
Q9TXQ1, TNKS1_CAEELO95271, TNKS1_HUMANQ6PFX9, TNKS1_MOUSE
Q9H2K2, TNKS2_HUMANQ3UES3, TNKS2_MOUSEQ9VBP3, TNKS_DROME
Q54YW4, Y8045_DICDI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
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