ID   2.4.2.36
DE   NAD(+)--diphthamide ADP-ribosyltransferase.
AN   ADP-ribosyltransferase.
AN   mono(ADP-ribosyl)transferase.
CA   diphthamide-[translation elongation factor 2] + NAD(+) = H(+) + N-(ADP-D-
CA   ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide.
CC   -!- Dihtheria toxin and some other bacterial toxins catalyze this
CC       reaction, which inactivates translation elongation factor 2 (EF2).
CC   -!- The acceptor is diphthamide, a unique modification of a histidine
CC       residue in the elongation factor found in archaebacteria and all
CC       eukaryotes, but not in eubacteria. cf. EC 2.4.2.31.
CC   -!- The relevant histidine of EF2 is His(715) in mammals, His(699) in
CC       yeast and His(600) in Pyrococcus horikoshii.
DR   Q5EK40, CHXA_VIBCL ;  P00588, DTX_CORBE  ;  P00587, DTX_COROM  ;
DR   P11439, TOXA_PSEAE ;
//