ENZYME entry: EC 2.4.2.43

Accepted Name

lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase

Alternative Name(s)

4-amino-4-deoxy-L-arabinose lipid A transferase

lipid A 4-amino-4-deoxy-L-arabinosyltransferase

polymyxin resistance protein PmrK

undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase

undecaprenyl phosphate-alpha-L-Ara4N transferase

Reaction catalysed

4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IVA <=> lipid IIA + di-trans,octa-cis-undecaprenyl phosphate

Comment(s)

Integral membrane protein present in the inner membrane of certain Gram negative endobacteria.
In strains that do not produce 3-deoxy-D-manno-octulosonic acid (Kdo), the enzyme adds a single arabinose unit to the 1-phosphate moiety of the tetra-acylated lipid A precursor, lipid IVA.
In the presence of a Kdo disaccharide, the enzyme primarily adds an arabinose unit to the 4-phosphate of lipid A molecules.
The Salmonella typhimurium enzyme can add arabinose units to both positions.
Formerly EC 2.4.2.n1.

Cross-references

BRENDA

2.4.2.43

EC2PDB

2.4.2.43

ExplorEnz

2.4.2.43

PRIAM enzyme-specific profiles

2.4.2.43

KEGG Ligand Database for Enzyme Nomenclature

2.4.2.43

IUBMB Enzyme Nomenclature

2.4.2.43

IntEnz

2.4.2.43

MEDLINE

Find literature relating to 2.4.2.43

MetaCyc

2.4.2.43

Rhea expert-curated reactions

2.4.2.43

UniProtKB/Swiss-Prot

B4EUL1, ARNT1_PROMH	Q4KC80, ARNT1_PSEF5	Q3KCC9, ARNT1_PSEPF
Q2NWA9, ARNT1_SODGM	B4ETL9, ARNT2_PROMH	Q4K884, ARNT2_PSEF5
Q3KCB9, ARNT2_PSEPF	Q2NRV9, ARNT2_SODGM	A0KGY4, ARNT_AERHH
A4SQX1, ARNT_AERS4	A7ZP75, ARNT_ECO24	B7UFR9, ARNT_ECO27
B7MG24, ARNT_ECO45	B7LAS2, ARNT_ECO55	Q8XDZ1, ARNT_ECO57
B5YXQ0, ARNT_ECO5E	B7NNT6, ARNT_ECO7I	B7MXT9, ARNT_ECO81
B7M5T9, ARNT_ECO8A	B1X8X0, ARNT_ECODH	A8A2C4, ARNT_ECOHS
A1ADA9, ARNT_ECOK1	Q0TFI5, ARNT_ECOL5	Q8FFL9, ARNT_ECOL6
B1IXT0, ARNT_ECOLC	P76473, ARNT_ECOLI	B7N5M2, ARNT_ECOLU
B6I7K0, ARNT_ECOSE	B1LLL1, ARNT_ECOSM	Q1R9F8, ARNT_ECOUT
C5BDQ8, ARNT_EDWI9	A4WAM1, ARNT_ENT38	B2VBI7, ARNT_ERWT9
B7LM74, ARNT_ESCF3	B5XTL1, ARNT_KLEP3	A6TF96, ARNT_KLEP7
Q6D2F3, ARNT_PECAS	C6DAW3, ARNT_PECCP	Q7N3Q9, ARNT_PHOLL
Q48HY9, ARNT_PSE14	A6V1N8, ARNT_PSEA7	B7VBN0, ARNT_PSEA8
Q02R27, ARNT_PSEAB	Q9HY61, ARNT_PSEAE	Q4ZSZ0, ARNT_PSEU2
B5EZI0, ARNT_SALA4	A9MJC5, ARNT_SALAR	Q57M54, ARNT_SALCH
B5FNU1, ARNT_SALDC	B5R274, ARNT_SALEP	B5RCC6, ARNT_SALG2
B4TBG8, ARNT_SALHS	B4SYX3, ARNT_SALNS	Q5PNA8, ARNT_SALPA
A9N5B0, ARNT_SALPB	C0Q067, ARNT_SALPC	B5BCP4, ARNT_SALPK
B4TPI4, ARNT_SALSV	Q8Z538, ARNT_SALTI	O52327, ARNT_SALTY
A8GDR9, ARNT_SERP5	A8FRR0, ARNT_SHESH	B2TW40, ARNT_SHIB3
Q31YK0, ARNT_SHIBS	Q32DT1, ARNT_SHIDS	Q0T2M6, ARNT_SHIF8
Q83KB6, ARNT_SHIFL	Q3YZU9, ARNT_SHISS	Q8D339, ARNT_WIGBR
A1JPM4, ARNT_YERE8	A7FHH6, ARNT_YERP3	Q1C744, ARNT_YERPA
B2K5L1, ARNT_YERPB	Q8ZDX9, ARNT_YERPE	A9R091, ARNT_YERPG
Q1CIH9, ARNT_YERPN	A4TIM6, ARNT_YERPP	Q66A06, ARNT_YERPS
B1JJ32, ARNT_YERPY

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