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ENZYME

ENZYME entry: EC 2.4.2.59

Accepted Name
sulfide-dependent adenosine diphosphate thiazole synthase
Reaction catalysed
glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide
Comment(s)
  • This iron dependent enzyme, found in most archaea, is involved in the biosynthesis of thiamine phosphate.
  • The homologous enzyme from plants and fungi (EC 2.4.2.60) uses an intrinsic cysteine as sulfur donor and, unlike the archaeal enzyme, is a single turn-over enzyme.
Cross-references
BRENDA2.4.2.59
EC2PDB2.4.2.59
ExplorEnz2.4.2.59
PRIAM enzyme-specific profiles2.4.2.59
KEGG Ligand Database for Enzyme Nomenclature2.4.2.59
IUBMB Enzyme Nomenclature2.4.2.59
IntEnz2.4.2.59
MEDLINEFind literature relating to 2.4.2.59
MetaCyc2.4.2.59
Rhea expert-curated reactions2.4.2.59
UniProtKB/Swiss-Prot
O29556, THI4_ARCFUA8ZVP3, THI4_DESOHA7HMY3, THI4_FERNB
A6UV59, THI4_META3Q8TM19, THI4_METACQ46AR1, THI4_METBF
Q12U93, THI4_METBUF6BCS4, THI4_METIKQ58018, THI4_METJA
A4FWG7, THI4_METM5A9A9W1, THI4_METM6A6VGT9, THI4_METM7
Q8Q0B5, THI4_METMAA3CXS4, THI4_METMJQ6LXJ8, THI4_METMP
A4YIV7, THI4_METS5O27657, THI4_METTHA0B880, THI4_METTP
A6UPZ7, THI4_METVSQ9V0J8, THI4_PYRABQ8ZZM5, THI4_PYRAE
A4WKY7, THI4_PYRARA3MWF6, THI4_PYRCJQ8U0Q5, THI4_PYRFU
O59082, THI4_PYRHOA1RW13, THI4_PYRILB1YDX0, THI4_PYRNV
Q97ZY5, THI4_SACS2C4XIR5, THI4_SOLM1Q4JAF8, THI4_SULAC
C3N6N6, THI4_SULIAC4KIA7, THI4_SULIKC3MQY1, THI4_SULIL
C3MWW9, THI4_SULIMC3NGI6, THI4_SULINC3N749, THI4_SULIY
Q975R0, THI4_SULTOQ5JD25, THI4_THEKOQ9WZP4, THI4_THEMA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
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