ENZYME entry: EC 2.4.3.6

Accepted Name

N-acetyllactosaminide alpha-2,3-sialyltransferase

Alternative Name(s)

alpha2->3 sialyltransferase

cytidine monophosphoacetylneuraminate-beta- galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase

neolactotetraosylceramide alpha-2,3-sialyltransferase

Reaction catalysed

a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)

Comment(s)

The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl- D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids.
The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1.
Formerly EC 2.4.99.6.

Cross-references

BRENDA

2.4.3.6

EC2PDB

2.4.3.6

ExplorEnz

2.4.3.6

PRIAM enzyme-specific profiles

2.4.3.6

KEGG Ligand Database for Enzyme Nomenclature

2.4.3.6

IUBMB Enzyme Nomenclature

2.4.3.6

IntEnz

2.4.3.6

MEDLINE

Find literature relating to 2.4.3.6

MetaCyc

2.4.3.6

Rhea expert-curated reactions

2.4.3.6

UniProtKB/Swiss-Prot

Q48211, LST_HAEIN	P72074, LST_NEIGO	Q9JUV5, LST_NEIMA
P72097, LST_NEIMB	Q11206, SIA4C_HUMAN	Q91Y74, SIA4C_MOUSE
P61130, SIA4C_PANTR	P61131, SIA4C_RAT	Q11203, SIAT6_HUMAN
P97325, SIAT6_MOUSE	P61132, SIAT6_PANTR	Q02734, SIAT6_RAT

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-