ENZYME entry: EC 2.4.99.19

Accepted Name
Undecaprenyl-diphosphooligosaccharide--protein glycotransferase.
Reaction catalysed
Tritrans,heptacis-undecaprenyl diphosphooligosaccharide + [protein]-L-asparagine <=> tritrans,heptacis-undecaprenyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to protein L-asparagine
Cofactor(s)
Mn(2+) or Mg(2+).
Comment(s)
  • A bacterial enzyme that has been isolated from Campylobacter jejuni and Campylobacter lari.
  • It forms a glycoprotein by the transfer of a glucosyl-N- acetylgalactosaminyl-N,N'-diacetylbacillosamine (GalNAc(2)(Glc)GalNAc(3)diNAcBac) polysaccharide and related oligosaccharides to the side-chain of an L-asparagine residue in the sequence -Asp/Glu-Xaa-Asn-Xaa'-Ser/Thr- (Xaa and Xaa' not Pro) in nascent polypeptide chains.
  • Occurs on the external face of the plasma membrane.
  • The polyprenol involved is normally tritrans,heptacis-undecaprenol but a decaprenol is used by some species.
Cross-references
BRENDA2.4.99.19
EC2PDB2.4.99.19
ExplorEnz2.4.99.19
PRIAM enzyme-specific profiles2.4.99.19
KEGG Ligand Database for Enzyme Nomenclature2.4.99.19
IUBMB Enzyme Nomenclature2.4.99.19
IntEnz2.4.99.19
MEDLINEFind literature relating to 2.4.99.19
MetaCyc2.4.99.19
UniProtKB/Swiss-Prot
Q0P9C8, PGLB_CAMJE;  Q5HTX9, PGLB_CAMJR;  B9KDD4, PGLB_CAMLR;  

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