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ENZYME entry: EC 2.4.99.7

Accepted Name
Alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase.
Alternative Name(s)
Alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase.
Cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta- galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase.
NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase.
Sialyltransferase.
Sialyltransferase 3C.
Sialyltransferase 7D.
ST6GALNAC.
Reaction catalysed
CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R <=> CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-(N-acetyl-alpha-neuraminyl-(2->6))-N-acetyl-D-galactosaminyl-R
Comment(s)
  • Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl- galactosamine only when present in the structure of alpha-N-acetyl- neuraminyl-(2->3)-beta-galactosyl-(1->3)-N-acetylgalactosaminyl-R, where R may be protein or p-nitrophenol.
  • Not identical with EC 2.4.99.3.
Cross-references
BRENDA2.4.99.7
EC2PDB2.4.99.7
ExplorEnz2.4.99.7
PRIAM enzyme-specific profiles2.4.99.7
KEGG Ligand Database for Enzyme Nomenclature2.4.99.7
IUBMB Enzyme Nomenclature2.4.99.7
IntEnz2.4.99.7
MEDLINEFind literature relating to 2.4.99.7
MetaCyc2.4.99.7
UniProtKB/Swiss-Prot
Q9H4F1, SIA7D_HUMAN;  Q9R2B6, SIA7D_MOUSE;  

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