ENZYME entry: EC 2.5.1.104

Accepted Name
N(1)-aminopropylagmatine synthase.
Alternative Name(s)
ACAPT.
Agmatine aminopropyltransferase.
Agmatine/cadaverine aminopropyl transferase.
Triamine/agmatine aminopropyltransferase.
Reaction catalysed
S-adenosylmethioninamine + agmatine <=> S-methyl-5'-thioadenosine + N(1)-(3-aminopropyl)agmatine
Comment(s)
  • The enzyme is involved in the biosynthesis of spermidine from agmatine in some archaea and bacteria.
  • The enzyme from the Gram-negative bacterium Thermus thermophilus accepts agmatine, spermidine and norspermidine with similar catalytic efficiency.
  • The enzymes from the archaea Pyrococcus furiosus and Thermococcus kodakarensis prefer agmatine, but can utilize cadaverine, putrescine and propane-1,3-diamine with much lower catalytic efficiency.
  • Cf. EC 2.5.1.16 and EC 2.5.1.23.
Cross-references
BRENDA2.5.1.104
EC2PDB2.5.1.104
ExplorEnz2.5.1.104
PRIAM enzyme-specific profiles2.5.1.104
KEGG Ligand Database for Enzyme Nomenclature2.5.1.104
IUBMB Enzyme Nomenclature2.5.1.104
IntEnz2.5.1.104
MEDLINEFind literature relating to 2.5.1.104
MetaCyc2.5.1.104
UniProtKB/Swiss-Prot
Q8U4G1, SPEE_PYRFU;  Q5JFG9, SPEE_THEKO;  Q5SK28, SPEE_THET8;  

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