ENZYME entry: EC 2.5.1.113

Accepted Name
[CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase.
Alternative Name(s)
CysO-thiocarboxylate-dependent cysteine synthase.
Reaction catalysed
O-phospho-L-serine + [CysO sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH <=> [CysO sulfur-carrier protein]-Gly-NH-CH(2)-C(O)-S-L-cysteine + phosphate
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The enzyme participates in an alternative pathway for L-cysteine biosynthesis that involves a protein-bound thiocarboxylate as the sulfide donor.
  • The enzyme from the bacterium Mycobacterium tuberculosis also has very low activity with O(3)-acetyl-L-serine (cf. EC 2.5.1.65).
  • Formerly EC 2.5.1.n5.
Cross-references
BRENDA2.5.1.113
EC2PDB2.5.1.113
ExplorEnz2.5.1.113
PRIAM enzyme-specific profiles2.5.1.113
KEGG Ligand Database for Enzyme Nomenclature2.5.1.113
IUBMB Enzyme Nomenclature2.5.1.113
IntEnz2.5.1.113
MEDLINEFind literature relating to 2.5.1.113
MetaCyc2.5.1.113
UniProtKB/Swiss-Prot
P63874, CYSM_MYCBO;  P9WP52, CYSM_MYCTO;  P9WP53, CYSM_MYCTU;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-