ID 2.5.1.114 DE tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase. AN tRNA-yW synthesizing enzyme-2. CA 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = CA 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + CA H(+) + S-methyl-5'-thioadenosine. CC -!- The enzyme, which is found in all eukaryotes and in the majority of CC Euryarchaeota (but not in the Crenarchaeota), is involved in the CC hypermodification of the guanine nucleoside at position 37 of tRNA CC leading to formation of assorted wye bases. CC -!- This modification is essential for translational reading-frame CC maintenance. CC -!- The eukaryotic enzyme is involved in biosynthesis of the tricyclic CC base wybutosine, which is found only in tRNA(Phe). DR Q8W4K1, TYW23_ARATH; Q8H4D4, TYW23_ORYSJ; Q58D65, TYW2_BOVIN ; DR Q0P466, TYW2_DANRE ; Q53H54, TYW2_HUMAN ; Q4R3U8, TYW2_MACFA ; DR Q58952, TYW2_METJA ; Q8BG71, TYW2_MOUSE ; O58523, TYW2_PYRHO ; DR Q4V8B8, TYW2_RAT ; Q09832, TYW2_SCHPO ; Q04235, TYW2_YEAST ; //