ENZYME entry: EC 2.5.1.116

Accepted Name
Homogentisate geranylgeranyltransferase.
Alternative Name(s)
HGGT.
Reaction catalysed
Geranylgeranyl diphosphate + homogentisate <=> diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO(2)
Cofactor(s)
Mg(2+).
Comment(s)
  • Involved in the biosynthesis of the vitamin E, tocotrienols.
  • While the enzyme from the bacterium Synechocystis PCC 6803 has higher activity with phytyl diphosphate (EC 2.5.1.115) the enzymes from barley, rice and wheat have only a low activity with that substrate.
Cross-references
BRENDA2.5.1.116
EC2PDB2.5.1.116
ExplorEnz2.5.1.116
PRIAM enzyme-specific profiles2.5.1.116
KEGG Ligand Database for Enzyme Nomenclature2.5.1.116
IUBMB Enzyme Nomenclature2.5.1.116
IntEnz2.5.1.116
MEDLINEFind literature relating to 2.5.1.116
MetaCyc2.5.1.116
UniProtKB/Swiss-Prot
Q7XB14, HGGT_HORVU;  Q0DAK7, HGGT_ORYSJ;  Q7XB13, HGGT_WHEAT;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
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