ENZYME entry: EC 2.5.1.127

Accepted Name
Caldopentamine synthase.
Alternative Name(s)
Long-chain polyamine synthase.
Reaction catalysed
S-adenosyl 3-(methylthio)propylamine + norspermine <=> S-methyl-5'-thioadenosine + caldopentamine
Comment(s)
  • The enzyme, characterized from the thermophilic archaeon Hyperthermus butylicus, can also synthesize norspermine from norspermidine and thermospermine from spermidine (with lower activity).
  • The long-chain polyamines stabilize double-stranded DNA at high temperatures.
  • In contrast to EC 2.5.1.23 and EC 2.5.1.126, this enzyme shows no activity with propane-1,3-diamine.
Cross-references
BRENDA2.5.1.127
EC2PDB2.5.1.127
ExplorEnz2.5.1.127
PRIAM enzyme-specific profiles2.5.1.127
KEGG Ligand Database for Enzyme Nomenclature2.5.1.127
IUBMB Enzyme Nomenclature2.5.1.127
IntEnz2.5.1.127
MEDLINEFind literature relating to 2.5.1.127
MetaCyc2.5.1.127
UniProtKB/Swiss-Prot
A2BIX4, SPEE1_HYPBU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
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