ENZYME entry: EC 2.5.1.128

Accepted Name
N(4)-bis(aminopropyl)spermidine synthase.
Reaction catalysed
2 S-adenosyl 3-(methylthio)propylamine + spermidine <=> 2 S-methyl-5'-thioadenosine + N(4)-bis(aminopropyl)spermidine
Comment(s)
  • The enzyme, characterized from the thermophilic archaeon Thermococcus kodakarensis, synthesizes the branched-chain polyamine N(4)- bis(aminopropyl)spermidine, which is required for cell growth at high-temperature.
  • When spermine is used as substrate, the enzyme forms N(4)- aminopropylspermine.
Cross-references
BRENDA2.5.1.128
EC2PDB2.5.1.128
ExplorEnz2.5.1.128
PRIAM enzyme-specific profiles2.5.1.128
KEGG Ligand Database for Enzyme Nomenclature2.5.1.128
IUBMB Enzyme Nomenclature2.5.1.128
IntEnz2.5.1.128
MEDLINEFind literature relating to 2.5.1.128
MetaCyc2.5.1.128
UniProtKB/Swiss-Prot
Q58669, BPSA_METJA;  Q5JIZ3, BPSA_THEKO;  P25125, BPSA_THETH;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
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