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ENZYME

ENZYME entry: EC 2.5.1.149

Accepted Name
lycopene elongase/hydratase (flavuxanthin-forming)
Reaction catalysed
  • A + all-trans-lycopene + dimethylallyl diphosphate + H2O <=> AH2 + diphosphate + nonaflavuxanthin
  • A + dimethylallyl diphosphate + H2O + nonaflavuxanthin <=> AH2 + diphosphate + flavuxanthin
Comment(s)
  • The enzyme, characterized from the bacterium Corynebacterium glutamicum, is bifunctional.
  • It catalyzes the elongation of the C40 carotenoid all-trans-lycopene by attaching an isoprene unit at C-2, as well as the hydroxylation of the new isoprene unit.
  • The enzyme acts at both ends of the substrate, forming the C50 carotenoid flavuxanthin via the C45 intermediate nonaflavuxanthin. cf. EC 2.5.1.150.
Cross-references
BRENDA2.5.1.149
EC2PDB2.5.1.149
ExplorEnz2.5.1.149
PRIAM enzyme-specific profiles2.5.1.149
KEGG Ligand Database for Enzyme Nomenclature2.5.1.149
IUBMB Enzyme Nomenclature2.5.1.149
IntEnz2.5.1.149
MEDLINEFind literature relating to 2.5.1.149
MetaCyc2.5.1.149
Rhea expert-curated reactions2.5.1.149
UniProtKB/Swiss-Prot
Q8NSP8, CRTEB_CORGLQ93QX2, CRTEB_CORGT

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