ENZYME entry: EC 2.5.1.15

Accepted Name
Dihydropteroate synthase.
Alternative Name(s)
DHPS.
Dihydropteroate diphosphorylase.
Dihydropteroate pyrophosphorylase.
Reaction catalysed
6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate <=> diphosphate + dihydropteroate
Comment(s)
  • The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea).
  • The enzyme exists in varying types of multifunctional proteins in different organisms.
  • The enzyme from the plant Arabidopsis thaliana also harbors the activity of EC 2.7.6.3, while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with the two above mentioned activities as well as EC 4.1.2.25.
Cross-references
PROSITEPDOC00630 ; PDOC50972
BRENDA2.5.1.15
EC2PDB2.5.1.15
ExplorEnz2.5.1.15
PRIAM enzyme-specific profiles2.5.1.15
KEGG Ligand Database for Enzyme Nomenclature2.5.1.15
IUBMB Enzyme Nomenclature2.5.1.15
IntEnz2.5.1.15
MEDLINEFind literature relating to 2.5.1.15
MetaCyc2.5.1.15
UniProtKB/Swiss-Prot
P0C004, DHP1_CORGT;  P0C002, DHP1_ECOLX;  Q49184, DHP1_MYCFO;  
P0C003, DHP1_PSEAI;  P0AC11, DHP2_ECOLX;  P0AC12, DHP2_SHIFL;  
O25830, DHPRS_HELPY;  P0A579, DHPS1_MYCBO;  P0C0X1, DHPS1_MYCLE;  
P9WND0, DHPS1_MYCTO;  P9WND1, DHPS1_MYCTU;  P28822, DHPS_BACSU;  
Q05621, DHPS_CLOB8;  P0AC14, DHPS_ECOL6;  P0AC13, DHPS_ECOLI;  
P43776, DHPS_HAEIN;  Q9JT70, DHPS_NEIMA;  Q51161, DHPS_NEIMB;  
P57696, DHPS_NEIMC;  P0AC15, DHPS_SHIFL;  Q5HIG1, DHPS_STAAC;  
P64141, DHPS_STAAM;  P64142, DHPS_STAAN;  Q6GJF7, DHPS_STAAR;  
Q6GBX4, DHPS_STAAS;  O05701, DHPS_STAAU;  Q8NXZ2, DHPS_STAAW;  
Q5HRP0, DHPS_STAEQ;  Q8CMT7, DHPS_STAES;  Q59919, DHPS_STAHA;  
P0C0G1, DHPS_STRP1;  P0DB08, DHPS_STRP3;  Q5XCA8, DHPS_STRP6;  
Q8P152, DHPS_STRP8;  P05382, DHPS_STRPN;  P0DB09, DHPS_STRPQ;  
P0C0G0, DHPS_STRPY;  P59655, DHPS_STRR6;  P73248, DHPS_SYNY3;  
Q54YD9, FOL1_DICDI;  P29251, FOL1_PNECA;  Q4LB35, FOL1_SCHPO;  
P53848, FOL1_YEAST;  Q9HS44, FOLCP_HALSA;  D4GW05, FOLCP_HALVD;  
Q1ENB6, FOLC_ARATH;  Q821E2, FOLKP_CHLCV;  P82602, FOLKP_CHLMU;  
Q9Z7E8, FOLKP_CHLPN;  O84619, FOLKP_CHLTR;  Q9SZV3, FOLM_ARATH;  
O04862, FOLM_PEA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
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