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ENZYME

ENZYME entry: EC 2.5.1.150

Accepted Name
lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming)
Reaction catalysed
  • all-trans-lycopene + dimethylallyl diphosphate + H2O <=> dihydroisopentenyldehydrorhodopin + diphosphate
  • dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin <=> dihydrobisanhydrobacterioruberin + diphosphate
Comment(s)
  • The enzyme, characterized from the bacterium Dietzia sp. CQ4 and the halophilic archaea Halobacterium salinarum and Haloarcula japonica, is bifunctional.
  • It catalyzes the elongation of the C40 carotenoid all-trans-lycopene by attaching an isoprene unit at C-2 as well as the hydroxylation of the previous end of the molecule.
  • The enzyme acts at both ends of the substrate, and combined with the action of EC 1.3.99.37, it forms the C50 carotenoid dihydrobisanhydrobacterioruberin. cf. EC 2.5.1.149.
Cross-references
BRENDA2.5.1.150
EC2PDB2.5.1.150
ExplorEnz2.5.1.150
PRIAM enzyme-specific profiles2.5.1.150
KEGG Ligand Database for Enzyme Nomenclature2.5.1.150
IUBMB Enzyme Nomenclature2.5.1.150
IntEnz2.5.1.150
MEDLINEFind literature relating to 2.5.1.150
MetaCyc2.5.1.150
Rhea expert-curated reactions2.5.1.150
UniProtKB/Swiss-Prot
A1XI30, LBTBC_DIESCM0L7V9, LYEL_HALJTQ9HPD9, LYEL_HALSA
D4GTV9, LYEL_HALVD

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