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ENZYME

ENZYME entry: EC 2.5.1.156

Accepted Name
geranylfarnesylglycerol-phosphate geranylfarnesyltransferase
Alternative Name(s)
2,3-bis-O-(farnesylgeranyl)-sn-glycerol 1-phosphate synthase
2,3-di-O-farnesylgeranylglyceryl synthase
DGFGP synthase
Reaction catalysed
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate <=> 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate
Comment(s)
  • The enzyme, characterized from the archaeon Aeropyrum pernix, carries out the second prenyltransfer reaction involved in the formation of C25,C25 membrane diether-lipids in some archaea.
  • Requires a divalent metal cation, such as Mg(2+).
  • The enzyme cannot accept sn-3-(O-geranylgeranyl)glycerol 1-phosphate as the prenyl donor. cf. EC 2.5.1.42.
Cross-references
BRENDA2.5.1.156
EC2PDB2.5.1.156
ExplorEnz2.5.1.156
PRIAM enzyme-specific profiles2.5.1.156
KEGG Ligand Database for Enzyme Nomenclature2.5.1.156
IUBMB Enzyme Nomenclature2.5.1.156
IntEnz2.5.1.156
MEDLINEFind literature relating to 2.5.1.156
MetaCyc2.5.1.156
Rhea expert-curated reactions2.5.1.156

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-