ENZYME entry: EC 2.5.1.16

Accepted Name
Spermidine synthase.
Alternative Name(s)
Aminopropyltransferase.
Putrescine aminopropyltransferase.
Reaction catalysed
S-adenosyl 3-(methylthio)propylamine + putrescine <=> 5'-S-methyl-5'-thioadenosine + spermidine
Comment(s)
  • The enzymes from the plant Glycine max and from mammalia are highly specific for putrescine as the amine acceptor.
  • The enzymes from the bacteria Escherichia coli and Thermotoga maritima prefer putrescine but are more tolerant toward other amine acceptors, such as spermidine and cadaverine.
  • Cf. EC 2.5.1.22 and EC 2.5.1.23.
Cross-references
PROSITEPDOC01033
BRENDA2.5.1.16
EC2PDB2.5.1.16
ExplorEnz2.5.1.16
PRIAM enzyme-specific profiles2.5.1.16
KEGG Ligand Database for Enzyme Nomenclature2.5.1.16
IUBMB Enzyme Nomenclature2.5.1.16
IntEnz2.5.1.16
MEDLINEFind literature relating to 2.5.1.16
MetaCyc2.5.1.16
UniProtKB/Swiss-Prot
Q9ZUB3, SPD1_ARATH;  Q96556, SPD1_DATST;  O48658, SPD1_HYONI;  
Q9SMB1, SPD1_ORYSJ;  Q9ZTR1, SPD1_PEA;  O48661, SPD2_ARATH;  
Q96557, SPD2_DATST;  O48659, SPD2_HYONI;  Q9ZTR0, SPD2_PEA;  
O82147, SPDE_COFAR;  O48660, SPDE_NICSY;  Q9ZS45, SPDE_SOLLC;  
O66473, SPEE1_AQUAE;  Q81JT0, SPEE1_BACAN;  Q814Q1, SPEE1_BACCR;  
Q8EZP1, SPEE1_LEPIN;  Q9X6R0, SPEE1_PSEAE;  Q8XQC5, SPEE1_RALSO;  
Q9L091, SPEE1_STRCO;  Q8RA94, SPEE1_THETN;  O67365, SPEE2_AQUAE;  
Q81X05, SPEE2_BACAN;  Q815E8, SPEE2_BACCR;  Q8EXA3, SPEE2_LEPIN;  
Q9HV34, SPEE2_PSEAE;  Q8XQC8, SPEE2_RALSO;  Q9X8S2, SPEE2_STRCO;  
Q8R977, SPEE2_THETN;  Q9YE02, SPEE_AERPE;  Q0ACK7, SPEE_ALKEH;  
A6TRI3, SPEE_ALKMQ;  A8MLM9, SPEE_ALKOO;  O27950, SPEE_ARCFU;  
Q72X78, SPEE_BACC1;  A7GVB2, SPEE_BACCN;  Q9K6B8, SPEE_BACHD;  
Q5WB31, SPEE_BACSK;  P70998, SPEE_BACSU;  A9VSG3, SPEE_BACWK;  
Q8G4L4, SPEE_BIFLO;  B8D908, SPEE_BUCA5;  P57305, SPEE_BUCAI;  
Q8K9T5, SPEE_BUCAP;  B8D7B3, SPEE_BUCAT;  B9MRW0, SPEE_CALBD;  
A4XKM9, SPEE_CALS8;  Q7NQK7, SPEE_CHRVO;  A8ALG8, SPEE_CITK8;  
Q97FX3, SPEE_CLOAB;  A6M1N9, SPEE_CLOB8;  B2V328, SPEE_CLOBA;  
B2TMY2, SPEE_CLOBB;  Q18A85, SPEE_CLOD6;  B9E5S1, SPEE_CLOK1;  
A5N219, SPEE_CLOK5;  Q0TTQ7, SPEE_CLOP1;  Q8XMY8, SPEE_CLOPE;  
A9KQ99, SPEE_CLOPH;  Q0SVK7, SPEE_CLOPS;  Q891W4, SPEE_CLOTE;  
A3DDA0, SPEE_CLOTH;  Q8FMF7, SPEE_COREF;  B1I5Z0, SPEE_DESAP;  
Q9XY92, SPEE_DICDI;  A7ZHL0, SPEE_ECO24;  B7UIG9, SPEE_ECO27;  
B7MBA4, SPEE_ECO45;  B7LFY8, SPEE_ECO55;  P66834, SPEE_ECO57;  
B5YZF6, SPEE_ECO5E;  B7NI81, SPEE_ECO7I;  B7MNY3, SPEE_ECO81;  
B7M162, SPEE_ECO8A;  C4ZRL4, SPEE_ECOBW;  B1XC96, SPEE_ECODH;  
A7ZW70, SPEE_ECOHS;  A1A7G7, SPEE_ECOK1;  Q0TLL3, SPEE_ECOL5;  
P66833, SPEE_ECOL6;  B1IQL9, SPEE_ECOLC;  P09158, SPEE_ECOLI;  
B7N7Z1, SPEE_ECOLU;  B6HZ96, SPEE_ECOSE;  B1LGS2, SPEE_ECOSM;  
Q1RG70, SPEE_ECOUT;  A4W6M6, SPEE_ENT38;  B2VD21, SPEE_ERWT9;  
B7LVY5, SPEE_ESCF3;  C4Z1Q7, SPEE_EUBE2;  C4ZDU4, SPEE_EUBR3;  
A1WZR2, SPEE_HALHL;  C4K3X3, SPEE_HAMD5;  Q17WL9, SPEE_HELAH;  
B6JM63, SPEE_HELP2;  B5Z7J7, SPEE_HELPG;  Q1CT37, SPEE_HELPH;  
Q9ZL11, SPEE_HELPJ;  B2USZ6, SPEE_HELPS;  O25503, SPEE_HELPY;  
P19623, SPEE_HUMAN;  B4U8W2, SPEE_HYDS0;  B5Y1R1, SPEE_KLEP3;  
A6T4R6, SPEE_KLEP7;  B1L5H2, SPEE_KORCO;  B0SI93, SPEE_LEPBA;  
B0STV8, SPEE_LEPBP;  Q72V65, SPEE_LEPIC;  Q606H1, SPEE_METCA;  
Q57761, SPEE_METJA;  Q2RHH3, SPEE_MOOTA;  Q64674, SPEE_MOUSE;  
Q7TY95, SPEE_MYCBO;  P9WGE4, SPEE_MYCTO;  P9WGE5, SPEE_MYCTU;  
P60593, SPEE_NEIMA;  P60594, SPEE_NEIMB;  Q9Y8H7, SPEE_NEUCR;  
Q82XD4, SPEE_NITEU;  Q3JDL8, SPEE_NITOC;  Q8CV14, SPEE_OCEIH;  
Q6D1W4, SPEE_PECAS;  C6DC58, SPEE_PECCP;  Q7N892, SPEE_PHOLL;  
Q6L1F4, SPEE_PICTO;  A3PFH4, SPEE_PROM0;  A2C5F4, SPEE_PROM1;  
A8G7J0, SPEE_PROM2;  A2CDX0, SPEE_PROM3;  A2BZ72, SPEE_PROM5;  
Q317V6, SPEE_PROM9;  Q7V9I5, SPEE_PROMA;  Q7V3X3, SPEE_PROMM;  
Q7UZI0, SPEE_PROMP;  A2BTR7, SPEE_PROMS;  Q46IA2, SPEE_PROMT;  
Q884N3, SPEE_PSESM;  Q9V277, SPEE_PYRAB;  Q8ZXM4, SPEE_PYRAE;  
A4WHN0, SPEE_PYRAR;  A3MU81, SPEE_PYRCJ;  Q8U4G1, SPEE_PYRFU;  
O57950, SPEE_PYRHO;  A1RU43, SPEE_PYRIL;  B1YB61, SPEE_PYRNV;  
Q7UWD1, SPEE_RHOBA;  Q1GGU4, SPEE_RUEST;  B5F815, SPEE_SALA4;  
A9MPN3, SPEE_SALAR;  Q57T89, SPEE_SALCH;  B5FIB4, SPEE_SALDC;  
B5R2R5, SPEE_SALEP;  B5RHA5, SPEE_SALG2;  B4TJD2, SPEE_SALHS;  
B4SU91, SPEE_SALNS;  Q5PDA0, SPEE_SALPA;  A9MZR2, SPEE_SALPB;  
C0Q5M7, SPEE_SALPC;  B5BL97, SPEE_SALPK;  B4TXL7, SPEE_SALSV;  
Q8Z9E2, SPEE_SALTI;  Q8ZRS3, SPEE_SALTY;  Q09741, SPEE_SCHPO;  
A8GJ06, SPEE_SERP5;  Q8EAX8, SPEE_SHEON;  B2U2X0, SPEE_SHIB3;  
Q326B5, SPEE_SHIBS;  Q32K90, SPEE_SHIDS;  Q0T879, SPEE_SHIF8;  
Q83MF0, SPEE_SHIFL;  Q3Z5N9, SPEE_SHISS;  Q2NVS1, SPEE_SODGM;  
Q82EU4, SPEE_STRAW;  B4SM23, SPEE_STRM5;  B2FKR1, SPEE_STRMK;  
P66835, SPEE_STRPN;  P66836, SPEE_STRR6;  B9DUY3, SPEE_STRU0;  
Q4JAZ8, SPEE_SULAC;  C3N5P4, SPEE_SULIA;  C4KHC0, SPEE_SULIK;  
C3MQ26, SPEE_SULIL;  C3MVE5, SPEE_SULIM;  C3NHE1, SPEE_SULIN;  
C3NEA8, SPEE_SULIY;  Q9UXE4, SPEE_SULSO;  Q975S5, SPEE_SULTO;  
Q31QK9, SPEE_SYNE7;  Q2JQS1, SPEE_SYNJA;  Q2JQ57, SPEE_SYNJB;  
Q5N3N4, SPEE_SYNP6;  Q7U3L0, SPEE_SYNPX;  Q0I685, SPEE_SYNS3;  
Q9HL75, SPEE_THEAC;  Q5JFG9, SPEE_THEKO;  Q9WZC2, SPEE_THEMA;  
B9KAY3, SPEE_THENN;  B6YXJ9, SPEE_THEON;  A5IJD3, SPEE_THEP1;  
B0K9I5, SPEE_THEP3;  B0K172, SPEE_THEPX;  Q72K55, SPEE_THET2;  
Q5SK28, SPEE_THET8;  Q97BN7, SPEE_THEVO;  B8GQ45, SPEE_THISH;  
Q8D3Q3, SPEE_VIBVU;  Q7MF74, SPEE_VIBVY;  Q7M7Q6, SPEE_WOLSU;  
Q8PFQ4, SPEE_XANAC;  Q3BN93, SPEE_XANC5;  Q4UPN0, SPEE_XANC8;  
B0RXN7, SPEE_XANCB;  Q8P447, SPEE_XANCP;  Q2P928, SPEE_XANOM;  
B2SHF6, SPEE_XANOP;  Q5H6E7, SPEE_XANOR;  B2I6M0, SPEE_XYLF2;  
Q9PH03, SPEE_XYLFA;  B0U1H5, SPEE_XYLFM;  Q87F26, SPEE_XYLFT;  
Q12074, SPEE_YEAST;  A1JJM8, SPEE_YERE8;  A7FM33, SPEE_YERP3;  
Q1C3U7, SPEE_YERPA;  B2K4I2, SPEE_YERPB;  Q8ZBJ8, SPEE_YERPE;  
A9R1H4, SPEE_YERPG;  Q1CLX1, SPEE_YERPN;  A4TPU4, SPEE_YERPP;  
Q66EH3, SPEE_YERPS;  B1JK45, SPEE_YERPY;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-