ENZYME entry: EC 2.5.1.18

Accepted Name
Glutathione transferase.
Alternative Name(s)
Glutathione S-alkyltransferase.
Glutathione S-aralkyltransferase.
Glutathione S-aryltransferase.
S-(hydroxyalkyl)glutathione lyase.
Reaction catalysed
RX + glutathione <=> HX + R-S-glutathione
Comment(s)
  • A group of enzymes of broad specificity.
  • R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
  • Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange.
  • Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.
Cross-references
BRENDA2.5.1.18
EC2PDB2.5.1.18
ExplorEnz2.5.1.18
PRIAM enzyme-specific profiles2.5.1.18
KEGG Ligand Database for Enzyme Nomenclature2.5.1.18
IUBMB Enzyme Nomenclature2.5.1.18
IntEnz2.5.1.18
MEDLINEFind literature relating to 2.5.1.18
MetaCyc2.5.1.18
UniProtKB/Swiss-Prot
Q9FWR4, DHAR1_ARATH;  Q9FRL8, DHAR2_ARATH;  Q8LE52, DHAR3_ARATH;  
Q9FG59, DHAR4_ARATH;  Q9I4K6, FOSA_PSEAE;  Q56415, FOSA_SERMA;  
O77462, GST1A_ANOGA;  O77473, GST1B_ANOGA;  Q93112, GST1C_ANOGA;  
Q93113, GST1D_ANOGA;  P46436, GST1_ASCSU;  O18598, GST1_BLAGE;  
P41043, GST1_DROME;  P46434, GST1_ONCVO;  Q9Y7Q2, GST1_SCHPO;  
P40582, GST1_YEAST;  Q9FQA3, GST23_MAIZE;  P30112, GST26_FASHE;  
P08515, GST26_SCHJA;  P15964, GST26_SCHMA;  P31670, GST27_FASHE;  
P35661, GST27_SCHMA;  P31671, GST28_FASHE;  P30113, GST28_SCHBO;  
P30114, GST28_SCHHA;  P26624, GST28_SCHJA;  P09792, GST28_SCHMA;  
P56598, GST29_FASHE;  P48429, GST2_ASCSU;  O16115, GST2_CAEEL;  
P0CG29, GST2_HUMAN;  P46429, GST2_MANSE;  O59827, GST2_SCHPO;  
Q12390, GST2_YEAST;  Q09607, GST36_CAEEL;  O16116, GST3_CAEEL;  
Q9P6M1, GST3_SCHPO;  Q21355, GST4_CAEEL;  Q09596, GST5_CAEEL;  
P20137, GST5_CHICK;  P82607, GST67_DICLA;  P91252, GST6_CAEEL;  
P91253, GST7_CAEEL;  P82608, GST82_DICLA;  P91254, GST8_CAEEL;  
Q21743, GST9_CAEEL;  P80894, GSTA1_ANTST;  Q28035, GSTA1_BOVIN;  
P81706, GSTA1_CAVPO;  Q08392, GSTA1_CHICK;  Q55FF3, GSTA1_DICDI;  
P08263, GSTA1_HUMAN;  P13745, GSTA1_MOUSE;  P51781, GSTA1_PIG;  
Q08863, GSTA1_RABIT;  P00502, GSTA1_RAT;  O18879, GSTA2_BOVIN;  
Q08393, GSTA2_CHICK;  Q556G3, GSTA2_DICDI;  P09210, GSTA2_HUMAN;  
P10648, GSTA2_MOUSE;  P04903, GSTA2_RAT;  P26697, GSTA3_CHICK;  
Q54VI4, GSTA3_DICDI;  Q16772, GSTA3_HUMAN;  P30115, GSTA3_MOUSE;  
P04904, GSTA3_RAT;  Q5E9G0, GSTA4_BOVIN;  Q86AU1, GSTA4_DICDI;  
O15217, GSTA4_HUMAN;  P24472, GSTA4_MOUSE;  P14942, GSTA4_RAT;  
Q54QV7, GSTA5_DICDI;  Q7RTV2, GSTA5_HUMAN;  P46418, GSTA5_RAT;  
Q6AXY0, GSTA6_RAT;  P0A9D3, GSTA_ECO57;  P0A9D2, GSTA_ECOLI;  
P30568, GSTA_PLEPL;  Q08862, GSTA_RABIT;  P0ACA8, GSTB_ECOL6;  
P0ACA7, GSTB_ECOLI;  P0ACA9, GSTB_SHIFL;  P82999, GSTE1_PSEUO;  
P83000, GSTE2_PSEUO;  P83001, GSTE_PSEFL;  P82998, GSTE_PSEP1;  
P82996, GSTE_PSEPU;  P82997, GSTE_PSEUF;  P42769, GSTF1_ARATH;  
P12653, GSTF1_MAIZE;  O65857, GSTF1_ORYSJ;  P84983, GSTF1_POPEU;  
P30109, GSTF1_TOBAC;  P30110, GSTF1_WHEAT;  P46422, GSTF2_ARATH;  
O82451, GSTF2_ORYSJ;  P84984, GSTF2_POPEU;  P46440, GSTF2_TOBAC;  
P30111, GSTF2_WHEAT;  Q9SLM6, GSTF3_ARATH;  P04907, GSTF3_MAIZE;  
Q84TK0, GSTF4_ARATH;  P46420, GSTF4_MAIZE;  Q9SRY6, GSTF5_ARATH;  
P42760, GSTF6_ARATH;  Q9SRY5, GSTF7_ARATH;  Q96266, GSTF8_ARATH;  
O80852, GSTF9_ARATH;  P42761, GSTFA_ARATH;  Q96324, GSTFB_ARATH;  
Q9FE46, GSTFC_ARATH;  Q9LZI9, GSTFD_ARATH;  Q9C6C8, GSTFE_ARATH;  
P48438, GSTF_BRAOT;  P46423, GSTF_HYOMU;  Q04522, GSTF_SILVU;  
Q09652, GSTK1_CAEEL;  Q9Y2Q3, GSTK1_HUMAN;  Q9DCM2, GSTK1_MOUSE;  
P24473, GSTK1_RAT;  Q18973, GSTK2_CAEEL;  Q6NLB0, GSTL1_ARATH;  
Q9M2W2, GSTL2_ARATH;  Q9LZ06, GSTL3_ARATH;  Q9N0V4, GSTM1_BOVIN;  
P46419, GSTM1_DERPT;  P09488, GSTM1_HUMAN;  Q9TSM5, GSTM1_MACFA;  
P10649, GSTM1_MOUSE;  P04905, GSTM1_RAT;  P20136, GSTM2_CHICK;  
P28161, GSTM2_HUMAN;  Q9TSM4, GSTM2_MACFA;  Q9BEB0, GSTM2_MACFU;  
P15626, GSTM2_MOUSE;  Q5R8E8, GSTM2_PONAB;  P08010, GSTM2_RAT;  
P21266, GSTM3_HUMAN;  Q9BEA9, GSTM3_MACFU;  Q03013, GSTM4_HUMAN;  
P19639, GSTM4_MOUSE;  P08009, GSTM4_RAT;  P46439, GSTM5_HUMAN;  
P86214, GSTM5_MESAU;  P48774, GSTM5_MOUSE;  Q9Z1B2, GSTM5_RAT;  
O35660, GSTM6_MOUSE;  Q80W21, GSTM7_MOUSE;  P16413, GSTMU_CAVPO;  
Q00285, GSTMU_CRILO;  P30116, GSTMU_MESAU;  P46409, GSTMU_RABIT;  
P34345, GSTO1_CAEEL;  P78417, GSTO1_HUMAN;  O09131, GSTO1_MOUSE;  
Q9N1F5, GSTO1_PIG;  Q9Z339, GSTO1_RAT;  A8XT16, GSTO2_CAEBR;  
P34277, GSTO2_CAEEL;  Q9H4Y5, GSTO2_HUMAN;  Q8K2Q2, GSTO2_MOUSE;  
Q6AXV9, GSTO2_RAT;  P81124, GSTO_APLCA;  P28801, GSTP1_BOVIN;  
P81942, GSTP1_BUFBU;  P10299, GSTP1_CAEEL;  Q9TTY8, GSTP1_CAPHI;  
P46424, GSTP1_CRILO;  P47954, GSTP1_CRIMI;  P09211, GSTP1_HUMAN;  
Q28514, GSTP1_MACMU;  Q60550, GSTP1_MESAU;  P19157, GSTP1_MOUSE;  
P80031, GSTP1_PIG;  Q5R8R5, GSTP1_PONAB;  P04906, GSTP1_RAT;  
Q8JFZ2, GSTP1_XENLA;  P83325, GSTP2_BUFBU;  P46425, GSTP2_MOUSE;  
Q9N4X8, GSTPA_CAEEL;  P46426, GSTP_DIRIM;  P46427, GSTP_ONCVO;  
Q9ZRT5, GSTT1_ARATH;  Q2NL00, GSTT1_BOVIN;  P20135, GSTT1_CHICK;  
P30104, GSTT1_DROER;  P67804, GSTT1_DROMA;  P20432, GSTT1_DROME;  
P30106, GSTT1_DROSE;  P67805, GSTT1_DROSI;  P30107, GSTT1_DROTE;  
P30108, GSTT1_DROYA;  P30711, GSTT1_HUMAN;  P42860, GSTT1_LUCCU;  
P46430, GSTT1_MANSE;  Q64471, GSTT1_MOUSE;  P28338, GSTT1_MUSDO;  
Q01579, GSTT1_RAT;  Q94999, GSTT2_ANOGA;  Q8L727, GSTT2_ARATH;  
Q9VG98, GSTT2_DROME;  P0CG30, GSTT2_HUMAN;  Q61133, GSTT2_MOUSE;  
P46431, GSTT2_MUSDO;  P30713, GSTT2_RAT;  Q9FHE1, GSTT3_ARATH;  
Q9VG97, GSTT3_DROME;  P46432, GSTT3_MUSDO;  Q9VG96, GSTT4_DROME;  
Q9D4P7, GSTT4_MOUSE;  P46433, GSTT4_MUSDO;  Q4V8E6, GSTT4_RAT;  
Q9VG95, GSTT5_DROME;  Q9VG94, GSTT6_DROME;  O76483, GSTT7_ANOGA;  
Q9VG93, GSTT7_DROME;  Q9ZW30, GSTU1_ARATH;  A2XMN2, GSTU1_ORYSI;  
Q10CE7, GSTU1_ORYSJ;  Q9ZW29, GSTU2_ARATH;  Q9ZW28, GSTU3_ARATH;  
Q9ZW27, GSTU4_ARATH;  P46421, GSTU5_ARATH;  Q9ZW26, GSTU6_ARATH;  
Q06398, GSTU6_ORYSJ;  Q9ZW24, GSTU7_ARATH;  Q9SR36, GSTU8_ARATH;  
Q9FUT0, GSTU9_ARATH;  Q9CA57, GSTUA_ARATH;  Q9CAS6, GSTUB_ARATH;  
Q6NMS0, GSTUC_ARATH;  Q9FUS6, GSTUD_ARATH;  Q9FUT1, GSTUE_ARATH;  
Q9LQ48, GSTUF_ARATH;  Q9XIF8, GSTUG_ARATH;  Q9FUS8, GSTUH_ARATH;  
Q9FUS9, GSTUI_ARATH;  Q9ZRW8, GSTUJ_ARATH;  Q8L7C9, GSTUK_ARATH;  
F4IA73, GSTUL_ARATH;  Q8GYM1, GSTUM_ARATH;  Q9M9F1, GSTUN_ARATH;  
Q9SHH6, GSTUO_ARATH;  Q9SHH7, GSTUP_ARATH;  Q9SHH8, GSTUQ_ARATH;  
Q9LZG7, GSTUR_ARATH;  Q9C8M3, GSTUS_ARATH;  P50471, GSTX1_NICPL;  
P32111, GSTX1_SOLTU;  Q03662, GSTX1_TOBAC;  P50472, GSTX2_MAIZE;  
Q03663, GSTX2_TOBAC;  P46417, GSTX3_SOYBN;  Q03664, GSTX3_TOBAC;  
Q03666, GSTX4_TOBAC;  P32110, GSTX6_SOYBN;  P25317, GSTXA_TOBAC;  
P49332, GSTXC_TOBAC;  P30102, GSTY2_ISSOR;  Q9ZVQ3, GSTZ1_ARATH;  
P28342, GSTZ1_DIACA;  Q9ZVQ4, GSTZ2_ARATH;  Q03425, GSTZ2_DIACA;  
P57108, GSTZ_EUPES;  O04437, GSTZ_WHEAT;  Q6R4B4, GST_ALTAL;  
P46428, GST_ANOGA;  P83246, GST_ASADI;  D2YW48, GST_COCIM;  
P44521, GST_HAEIN;  P46437, GST_MUSDO;  P46088, GST_NOTSL;  
P81065, GST_OCHAN;  Q8ILQ7, GST_PLAF7;  Q8MU52, GST_PLAFA;  
Q0ZS46, GST_PLAVI;  Q7REH6, GST_PLAYO;  P15214, GST_PROMI;  
P22416, GST_SERMA;  P45875, GST_XANCP;  P48239, GTO1_YEAST;  
O94524, GTO2_SCHPO;  P36156, GTO2_YEAST;  Q04806, GTO3_YEAST;  
O73888, HPGDS_CHICK;  O60760, HPGDS_HUMAN;  Q9JHF7, HPGDS_MOUSE;  
O35543, HPGDS_RAT;  Q9VHD3, MAAI1_DROME;  Q9VHD2, MAAI2_DROME;  
O43708, MAAI_HUMAN;  Q9WVL0, MAAI_MOUSE;  P57113, MAAI_RAT;  
Q64L89, MGST1_BOVIN;  P10620, MGST1_HUMAN;  Q91VS7, MGST1_MOUSE;  
P79382, MGST1_PIG;  P08011, MGST1_RAT;  Q2KJG4, MGST2_BOVIN;  
Q99735, MGST2_HUMAN;  Q3T100, MGST3_BOVIN;  O14880, MGST3_HUMAN;  
Q9CPU4, MGST3_MOUSE;  Q54GA9, MGST_DICDI;  O80662, TCHQD_ARATH;  
O74830, YC12_SCHPO;  P77544, YFCF_ECOLI;  B5BP46, YP52_SCHPO;  

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