ID   2.5.1.25
DE   tRNA-uridine aminocarboxypropyltransferase.
CA   a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-
CA   carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine.
CC   -!- 3-[(3S)-3-amino-3-carboxypropyl]uridine (acp3U) is a highly conserved
CC       modification found in tRNA core region in bacteria and eukaryotes
CC       that confers thermal stability on tRNA.
CC   -!- The enzyme from the bacterium Escherichia coli catalyzes the
CC       modification of uridine(47) in the V-loop of tRNAs for Arg(2),
CC       Ile(1), Ile(2), Ile(2)v, Lys, Met, Phe, Val(2)A, and Val(2)B.
CC   -!- The human homologs DTWD1 and DTWD2 are responsible for acp3U
CC       formation at positions 20 and 20a, respectively, in the D-loop of
CC       several cytoplasmic tRNAs.
DR   F4IL05, DTW2A_ARATH;  Q5XJ56, DTWD1_DANRE;  Q8N5C7, DTWD1_HUMAN;
DR   Q9D8U7, DTWD1_MOUSE;  Q5RCQ0, DTWD1_PONAB;  Q6AYF5, DTWD1_RAT  ;
DR   Q6DDV1, DTWD1_XENLA;  Q28I29, DTWD1_XENTR;  Q9VI85, DTWD2_DROME;
DR   Q8NBA8, DTWD2_HUMAN;  Q4R7M4, DTWD2_MACFA;  Q9D0U1, DTWD2_MOUSE;
DR   Q47319, TAPT_ECOLI ;
//