ENZYME entry: EC 2.5.1.39

Accepted Name
4-hydroxybenzoate polyprenyltransferase.
Alternative Name(s)
4-hydroxybenzoate nonaprenyltransferase.
Reaction catalysed
A polyprenyl diphosphate + 4-hydroxybenzoate <=> diphosphate + a 4-hydroxy-3-polyprenylbenzoate
Comment(s)
  • This enzyme, involved in the biosynthesis of ubiquinone, attaches a polyprenyl side chain to a 4-hydroxybenzoate ring, producing the first ubiquinone intermediate that is membrane bound.
  • The number of isoprenoid subunits in the side chain varies in different species.
  • The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency.
Cross-references
PROSITEPDOC00727
BRENDA2.5.1.39
EC2PDB2.5.1.39
ExplorEnz2.5.1.39
PRIAM enzyme-specific profiles2.5.1.39
KEGG Ligand Database for Enzyme Nomenclature2.5.1.39
IUBMB Enzyme Nomenclature2.5.1.39
IntEnz2.5.1.39
MEDLINEFind literature relating to 2.5.1.39
MetaCyc2.5.1.39
UniProtKB/Swiss-Prot
Q16QL3, COQ2_AEDAE;  Q93YP7, COQ2_ARATH;  Q2KIQ4, COQ2_BOVIN;  
Q8I7J4, COQ2_CAEEL;  Q54U71, COQ2_DICDI;  Q9VHS7, COQ2_DROME;  
Q298G6, COQ2_DROPS;  Q96H96, COQ2_HUMAN;  Q66JT7, COQ2_MOUSE;  
Q499N4, COQ2_RAT;  Q10252, COQ2_SCHPO;  P32378, COQ2_YEAST;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-