ENZYME entry: EC 2.5.1.42

Accepted Name
Geranylgeranylglycerol-phosphate geranylgeranyltransferase.
Alternative Name(s)
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase.
DGGGP synthase.
DGGGPS.
Reaction catalysed
Geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate <=> diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • Carries out the second prenyltransfer reaction involved in the formation of polar membrane lipids in archaea.
  • 4-hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate and alpha-glycerophosphate cannot act as prenyl-acceptor substrates.
  • The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 1.1.1.261, EC 2.5.1.41, which, together with this enzyme, alkylates the hydroxy groups of glycerol 1-phosphate to yield unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 to form CDP-unsaturated archaeol.
  • The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine.
Cross-references
BRENDA2.5.1.42
EC2PDB2.5.1.42
ExplorEnz2.5.1.42
PRIAM enzyme-specific profiles2.5.1.42
KEGG Ligand Database for Enzyme Nomenclature2.5.1.42
IUBMB Enzyme Nomenclature2.5.1.42
IntEnz2.5.1.42
MEDLINEFind literature relating to 2.5.1.42
MetaCyc2.5.1.42
UniProtKB/Swiss-Prot
O29843, DGGGP_ARCFU;  B0R3S1, DGGGP_HALS3;  Q9HRP0, DGGGP_HALSA;  
Q18J00, DGGGP_HALWD;  A2BIU7, DGGGP_HYPBU;  A8A9J7, DGGGP_IGNH4;  
B1L6Z7, DGGGP_KORCO;  A6UVU6, DGGGP_META3;  Q8TS44, DGGGP_METAC;  
A7I9E7, DGGGP_METB6;  Q46BD9, DGGGP_METBF;  Q12VF3, DGGGP_METBU;  
Q2FN44, DGGGP_METHJ;  Q57727, DGGGP_METJA;  Q8TWS9, DGGGP_METKA;  
A2SRL0, DGGGP_METLZ;  A4G0P3, DGGGP_METM5;  A9A8Y7, DGGGP_METM6;  
A6VHU1, DGGGP_METM7;  Q8PV96, DGGGP_METMA;  A3CW74, DGGGP_METMJ;  
Q6LWN2, DGGGP_METMP;  A5ULR8, DGGGP_METS3;  A4YI21, DGGGP_METS5;  
Q2NGM1, DGGGP_METST;  O27170, DGGGP_METTH;  A0B8A0, DGGGP_METTP;  
A6UQV8, DGGGP_METVS;  Q3INH7, DGGGP_NATPD;  Q9V2P5, DGGGP_PYRAB;  
Q8TZM7, DGGGP_PYRFU;  O57753, DGGGP_PYRHO;  Q4J8K2, DGGGP_SULAC;  
Q9UWY6, DGGGP_SULSO;  Q971A3, DGGGP_SULTO;  C5A1J7, DGGGP_THEGJ;  
Q5JDN5, DGGGP_THEKO;  B6YW76, DGGGP_THEON;  A1S066, DGGGP_THEPD;  
C6A2C9, DGGGP_THESM;  

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