ENZYME entry: EC 2.5.1.44

Accepted Name
Homospermidine synthase.
Reaction catalysed
  • 2 putrescine <=> sym-homospermidine + NH(3) + H(+)
  • Putrescine + spermidine <=> sym-homospermidine + propane-1,3-diamine
Cofactor(s)
NAD(+).
Comment(s)
  • The reaction of this enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: NAD(+)-dependent dehydrogenation of putrescine, transfer of the 4-aminobutylidene group from dehydroputrescine to a second molecule of putrescine and reduction of the imine intermediate to form homospermidine.
  • Hence the overall reaction is transfer of a 4-aminobutyl group.
  • Differs from EC 2.5.1.45, which cannot use putrescine as donor of the aminobutyl group.
Cross-references
BRENDA2.5.1.44
EC2PDB2.5.1.44
ExplorEnz2.5.1.44
PRIAM enzyme-specific profiles2.5.1.44
KEGG Ligand Database for Enzyme Nomenclature2.5.1.44
IUBMB Enzyme Nomenclature2.5.1.44
IntEnz2.5.1.44
MEDLINEFind literature relating to 2.5.1.44
MetaCyc2.5.1.44
UniProtKB/Swiss-Prot
Q98H64, HSS_RHILO;  O32323, HSS_RHOVI;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
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