ENZYME

ENZYME entry: EC 2.5.1.58

Accepted Name

Protein farnesyltransferase.

Alternative Name(s)

CAAX farnesyltransferase.

FTase.

Reaction catalysed

Farnesyl diphosphate + protein-cysteine <=> S-farnesyl protein + diphosphate

Cofactor(s)

Magnesium; Zinc.

Comment(s)

This enzyme, along with EC 2.5.1.59 and EC 2.5.1.60, constitutes the protein prenyltransferase family of enzymes.
Catalyzes the formation of a thioether linkage between the C-1 of an isoprenyl group and a cysteine residue fourth from the C-terminus of the protein.
These protein acceptors have the C-terminal sequence CA(1)A(2)X, where the terminal residue, X, is preferably serine, methionine, alanine or glutamine; leucine makes the protein a substrate for EC 2.5.1.59.
The enzymes are relaxed in specificity for A(1), but cannot act if A(2) is aromatic.
Substrates of the prenyltransferases include Ras, Rho, Rab, other Ras-related small GTP-binding proteins, gamma-subunits of heterotrimeric G-proteins, nuclear lamins, centromeric proteins and many proteins involved in visual signal transduction.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz

MEDLINE

MetaCyc

UniProtKB/Swiss-Prot

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