ID   2.5.1.60
DE   Protein geranylgeranyltransferase type II.
AN   GGTaseII.
AN   Rab geranylgeranyltransferase.
AN   RabGGTase.
AN   Type II protein geranyl-geranyltransferase.
CA   Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-
CA   protein + diphosphate.
CC   -!- This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the
CC       protein prenyltransferase family of enzymes.
CC   -!- Attaches geranylgeranyl groups to two C-terminal cysteines in Ras-
CC       related GTPases of a single family, the Rab family (Ypt/Sec4 in lower
CC       eukaryotes) that terminate in XXCC, XCXC and CCXX motifs.
CC   -!- Reaction is entirely dependent on the Rab substrate being bound to
CC       Rab escort protein (REP).
CC   -!- Post-translational modification with the geranylgeranyl moiety is
CC       essential for Rab GTPases to be able to control the processes of
CC       membrane docking and fusion.
PR   PROSITE; PDOC00703;
DR   P41992, GGTB2_CAEEL;  Q5EA80, PGTA_BOVIN ;  O93829, PGTA_CANAX ;
DR   Q55DQ4, PGTA_DICDI ;  Q92696, PGTA_HUMAN ;  Q9JHK4, PGTA_MOUSE ;
DR   A5A779, PGTA_PIG   ;  Q5NVK5, PGTA_PONAB ;  Q08602, PGTA_RAT   ;
DR   O94412, PGTA_SCHPO ;  Q00618, PGTA_YEAST ;  Q5E9B3, PGTB2_BOVIN;
DR   O93830, PGTB2_CANAX;  B0G172, PGTB2_DICDI;  P53611, PGTB2_HUMAN;
DR   P53612, PGTB2_MOUSE;  Q08603, PGTB2_RAT  ;  P46960, PGTB2_SCHPO;
DR   P20133, PGTB2_YEAST;
//