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ENZYME entry: EC 2.5.1.74

Accepted Name
1,4-dihydroxy-2-naphthoate polyprenyltransferase.
Reaction catalysed
An all-trans-polyprenyl diphosphate + 1,4-dihydroxy-2-naphthoate <=> a demethylmenaquinol + diphosphate + CO(2)
Comment(s)
  • This enzyme catalyzes a step in the synthesis of menaquinone, in which the prenyl chain synthesized by polyprenyl diphosphate synthase is transferred to 1,4-dihydroxy-2-naphthoate (DHNA).
  • The bacterial enzyme is an inner membrane protein, with the C-terminus located in the periplasm.
  • It is highly specific for DHNA but not for a specific length of the prenyl chain.
Cross-references
BRENDA2.5.1.74
EC2PDB2.5.1.74
ExplorEnz2.5.1.74
PRIAM enzyme-specific profiles2.5.1.74
KEGG Ligand Database for Enzyme Nomenclature2.5.1.74
IUBMB Enzyme Nomenclature2.5.1.74
IntEnz2.5.1.74
MEDLINEFind literature relating to 2.5.1.74
MetaCyc2.5.1.74
UniProtKB/Swiss-Prot
P39582, MENA_BACSU;  P32166, MENA_ECOLI;  P44739, MENA_HAEIN;  
P65651, MENA_MYCBO;  O07134, MENA_MYCLE;  P9WIP2, MENA_MYCTO;  
P9WIP3, MENA_MYCTU;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-