ID   2.5.1.87
DE   ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl
DE   diphosphate specific].
AN   dehydrodolichyl diphosphate synthase 1.
AN   Rer2p Z-prenyltransferase.
CA   (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = di-trans,poly-
CA   cis-polyprenyl diphosphate + n diphosphate.
CC   -!- The enzyme is involved in biosynthesis of dolichol (a long-chain
CC       polyprenol) with a saturated alpha-isoprene unit, which serves as a
CC       glycosyl carrier in protein glycosylation.
CC   -!- The yeast Saccharomyces cerevisiae has two different enzymes that
CC       catalyze this reaction.
CC   -!- Rer2p synthesizes a well-defined family of polyprenols of 13-18
CC       isoprene residues with dominating C80 (16 isoprene residues)
CC       extending to C120, while Srt1p synthesizes mainly polyprenol with 22
CC       isoprene subunits.
CC   -!- Largest Srt1p products reach C290.
CC   -!- The enzyme from Arabidopsis thaliana catalyzes the formation of
CC       polyprenyl diphosphates with predominant carbon number C120.
DR   K7WCI9, CPT3_SOLLC ;  K7X479, CPT5_SOLLC ;  O80458, DDPS1_ARATH;
DR   Q86SQ9, DHDDS_HUMAN;  Q99KU1, DHDDS_MOUSE;  P60478, DPDS_MYCBO ;
DR   P38119, DPDS_MYCLE ;  A0R0S4, DPDS_MYCS2 ;  P9WFF6, DPDS_MYCTO ;
DR   P9WFF7, DPDS_MYCTU ;  Q6DHR8, NGBR_DANRE ;  Q96E22, NGBR_HUMAN ;
DR   Q99LJ8, NGBR_MOUSE ;  P35196, RER2_YEAST ;  Q03175, SRT1_YEAST ;
DR   Q9Y7K8, UPPS_SCHPO ;  Q12063, UPPS_YEAST ;  O14171, YE54_SCHPO ;
//