ENZYME entry: EC 2.6.1.16

Accepted Name
Glutamine--fructose-6-phosphate transaminase (isomerizing).
Alternative Name(s)
D-fructose-6-phosphate amidotransferase.
GlcN6P synthase.
Glucosamine-6-phosphate isomerase (glutamine-forming).
Glucosamine-6-phosphate synthase.
Hexosephosphate aminotransferase.
L-glutamine-D-fructose-6-phosphate amidotransferase.
Reaction catalysed
L-glutamine + D-fructose 6-phosphate <=> L-glutamate + D-glucosamine 6-phosphate
Comment(s)
  • Although the overall reaction is that of a transferase, the mechanism involves the formation of ketimine between fructose 6-phosphate and a 6-amino group from a lysine residue at the active site, which is subsequently displaced by ammonia (transamidination).
  • Formerly EC 5.3.1.19.
Cross-references
PROSITEPDOC00406 ; PDOC51464
BRENDA2.6.1.16
EC2PDB2.6.1.16
ExplorEnz2.6.1.16
PRIAM enzyme-specific profiles2.6.1.16
KEGG Ligand Database for Enzyme Nomenclature2.6.1.16
IUBMB Enzyme Nomenclature2.6.1.16
IntEnz2.6.1.16
MEDLINEFind literature relating to 2.6.1.16
MetaCyc2.6.1.16
UniProtKB/Swiss-Prot
P53704, GFA1_CANAL;  Q8SRI2, GFA1_ENCCU;  Q09740, GFA1_SCHPO;  
P14742, GFA1_YEAST;  Q7T6X6, GFAT_MIMIV;  Q06210, GFPT1_HUMAN;  
P47856, GFPT1_MOUSE;  P82808, GFPT1_RAT;  Q08DQ2, GFPT2_BOVIN;  
O94808, GFPT2_HUMAN;  Q9Z2Z9, GFPT2_MOUSE;  Q4KMC4, GFPT2_RAT;  
Q6F6U8, GLMS_ACIAD;  Q56275, GLMS_ACIFR;  Q9YCQ6, GLMS_AERPE;  
Q8UEH1, GLMS_AGRT5;  O66648, GLMS_AQUAE;  Q81VN5, GLMS_BACAN;  
Q73F49, GLMS_BACC1;  Q81J01, GLMS_BACCR;  Q9KG45, GLMS_BACHD;  
Q6HPL2, GLMS_BACHK;  Q65P46, GLMS_BACLD;  E0U070, GLMS_BACPZ;  
Q5WLG7, GLMS_BACSK;  P0CI73, GLMS_BACSU;  Q8AAB1, GLMS_BACTN;  
Q6G322, GLMS_BARHE;  Q6FZH6, GLMS_BARQU;  Q7WE36, GLMS_BORBR;  
Q7W334, GLMS_BORPA;  Q7VRZ3, GLMS_BORPE;  P59362, GLMS_BRADU;  
Q577Y1, GLMS_BRUAB;  Q8YC47, GLMS_BRUME;  Q8CY30, GLMS_BRUSU;  
P57138, GLMS_BUCAI;  Q8KA75, GLMS_BUCAP;  P59499, GLMS_BUCBP;  
Q8R841, GLMS_CALS4;  Q9PMT4, GLMS_CAMJE;  Q9ABV2, GLMS_CAUCR;  
Q5L589, GLMS_CHLAB;  Q821Z7, GLMS_CHLCV;  Q9PLA4, GLMS_CHLMU;  
Q9Z6U0, GLMS_CHLPN;  Q8KG38, GLMS_CHLTE;  O84823, GLMS_CHLTR;  
Q97MN6, GLMS_CLOAB;  Q8XHZ7, GLMS_CLOPE;  Q890U2, GLMS_CLOTE;  
Q6NG33, GLMS_CORDI;  Q8FNH2, GLMS_COREF;  Q8NND3, GLMS_CORGL;  
O19908, GLMS_CYACA;  Q8XEG2, GLMS_ECO57;  Q8FBT4, GLMS_ECOL6;  
P17169, GLMS_ECOLI;  Q5NHQ9, GLMS_FRATT;  Q8RG65, GLMS_FUSNN;  
Q5L3P0, GLMS_GEOKA;  Q74GH6, GLMS_GEOSL;  Q7NIG8, GLMS_GLOVI;  
Q5FUY5, GLMS_GLUOX;  Q7VKK4, GLMS_HAEDU;  P44708, GLMS_HAEIN;  
Q9HT00, GLMS_HALSA;  Q9ZJ94, GLMS_HELPJ;  O26060, GLMS_HELPY;  
Q5QZH5, GLMS_IDILO;  Q9CGT6, GLMS_LACLA;  Q88YE7, GLMS_LACPL;  
Q5X153, GLMS_LEGPA;  Q5ZRP4, GLMS_LEGPH;  Q5WSX8, GLMS_LEGPL;  
Q6AD32, GLMS_LEIXX;  Q72V57, GLMS_LEPIC;  Q8EZQ1, GLMS_LEPIN;  
Q92DS8, GLMS_LISIN;  Q722H1, GLMS_LISMF;  Q8Y915, GLMS_LISMO;  
Q8TLL3, GLMS_METAC;  Q58815, GLMS_METJA;  Q8TZ14, GLMS_METKA;  
Q8Q038, GLMS_METMA;  Q6LWM9, GLMS_METMP;  O26273, GLMS_METTH;  
P0A589, GLMS_MYCBO;  P40831, GLMS_MYCLE;  Q73S23, GLMS_MYCPA;  
O68956, GLMS_MYCS2;  P9WN48, GLMS_MYCTO;  P9WN49, GLMS_MYCTU;  
Q5F584, GLMS_NEIG1;  Q9JWN9, GLMS_NEIMA;  Q9K1P9, GLMS_NEIMB;  
O68280, GLMS_NOSS9;  Q8ETM5, GLMS_OCEIH;  P57963, GLMS_PASMU;  
Q6CYJ9, GLMS_PECAS;  Q7NA97, GLMS_PHOLL;  Q6LLH3, GLMS_PHOPR;  
Q9HT25, GLMS_PSEAE;  Q88BX8, GLMS_PSEPK;  Q87TT8, GLMS_PSESM;  
Q9V249, GLMS_PYRAB;  Q8ZTZ0, GLMS_PYRAE;  Q8U4D1, GLMS_PYRFU;  
O57981, GLMS_PYRHO;  Q8Y303, GLMS_RALSO;  Q98LX5, GLMS_RHILO;  
Q92PS4, GLMS_RHIME;  Q5PKV9, GLMS_SALPA;  Q8Z2Q2, GLMS_SALTI;  
Q8ZKX1, GLMS_SALTY;  Q8CX33, GLMS_SHEON;  Q83IY4, GLMS_SHIFL;  
Q56206, GLMS_SPHYA;  Q5HE49, GLMS_STAAC;  P64227, GLMS_STAAM;  
P64228, GLMS_STAAN;  Q6GES3, GLMS_STAAR;  Q6G7F8, GLMS_STAAS;  
Q8NVE6, GLMS_STAAW;  Q5HM69, GLMS_STAEQ;  Q8CRL1, GLMS_STAES;  
Q8E5P8, GLMS_STRA3;  Q8DZZ7, GLMS_STRA5;  O86781, GLMS_STRCO;  
Q8DTY0, GLMS_STRMU;  Q99ZD3, GLMS_STRP1;  P0DB32, GLMS_STRP3;  
Q5XBV6, GLMS_STRP6;  Q8P0S7, GLMS_STRP8;  Q97SQ9, GLMS_STRPN;  
P0DB33, GLMS_STRPQ;  Q8DRA8, GLMS_STRR6;  Q4J6D9, GLMS_SULAC;  
Q67T12, GLMS_SYMTH;  P72720, GLMS_SYNY3;  Q8DJI6, GLMS_THEEB;  
Q5JH71, GLMS_THEKO;  Q9WXZ5, GLMS_THEMA;  Q72HF4, GLMS_THET2;  
Q56213, GLMS_THET8;  O83833, GLMS_TREPA;  Q83IA1, GLMS_TROW8;  
Q83FU2, GLMS_TROWT;  Q9KUM8, GLMS_VIBCH;  Q5E279, GLMS_VIBF1;  
Q87SR3, GLMS_VIBPA;  Q8DEF3, GLMS_VIBVU;  Q7MP62, GLMS_VIBVY;  
Q8D3J0, GLMS_WIGBR;  Q8PGH9, GLMS_XANAC;  Q8PCY1, GLMS_XANCP;  
Q9PH05, GLMS_XYLFA;  Q87F28, GLMS_XYLFT;  Q8Z9S8, GLMS_YERPE;  
Q663R1, GLMS_YERPS;  Q5NRH4, GLMS_ZYMMO;  P94323, NODM_BRADU;  
Q52846, NODM_RHILT;  P08633, NODM_RHILV;  Q92ZK3, NODM_RHIME;  
P25195, NODM_RHIML;  B3LLX6, YM084_YEAS1;  C7GL41, YM084_YEAS2;  
A6ZME2, YM084_YEAS7;  C8ZET7, YM084_YEAS8;  A2P2R3, YM084_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.1.-
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