ENZYME entry: EC 2.6.1.52

Accepted Name
Phosphoserine transaminase.
Alternative Name(s)
3-phosphoserine aminotransferase.
3PHP transaminase.
Hydroxypyruvic phosphate--glutamic transaminase.
L-phosphoserine aminotransferase.
Phosphohydroxypyruvate transaminase.
Phosphohydroxypyruvic--glutamic transaminase.
Phosphoserine aminotransferase.
PSAT.
Reaction catalysed
  • O-phospho-L-serine + 2-oxoglutarate <=> 3-phosphonooxypyruvate + L-glutamate
  • 4-phosphonooxy-L-threonine + 2-oxoglutarate <=> (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • Catalyzes the second step in the phosphorylated pathway of serine biosynthesis in Escherichia coli.
  • Also catalyzes the third step in the biosynthesis of the coenzyme pyridoxal 5'-phosphate in E.coli (using reaction 2 above).
  • In E.coli, pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate).
  • Pyridoxal phosphate is the cofactor for both activities and therefore seems to be involved in its own biosynthesis.
  • Non-phosphorylated forms of serine and threonine are not substrates.
Cross-references
PROSITEPDOC00514
BRENDA2.6.1.52
EC2PDB2.6.1.52
ExplorEnz2.6.1.52
PRIAM enzyme-specific profiles2.6.1.52
KEGG Ligand Database for Enzyme Nomenclature2.6.1.52
IUBMB Enzyme Nomenclature2.6.1.52
IntEnz2.6.1.52
MEDLINEFind literature relating to 2.6.1.52
MetaCyc2.6.1.52
UniProtKB/Swiss-Prot
Q96255, SERB1_ARATH;  Q9SHP0, SERB2_ARATH;  A1TSA3, SERC_ACIAC;  
Q6F961, SERC_ACIAD;  B7GY87, SERC_ACIB3;  B7I5D6, SERC_ACIB5;  
B2HWW3, SERC_ACIBC;  A3M7Z0, SERC_ACIBT;  B7J6V1, SERC_ACIF2;  
B5EPR5, SERC_ACIF5;  Q5P7U7, SERC_AROAE;  B6YQL2, SERC_AZOPC;  
C1DRQ9, SERC_AZOVD;  C3P210, SERC_BACAA;  Q9RME2, SERC_BACAO;  
Q734W9, SERC_BACC1;  Q59196, SERC_BACCI;  Q81BC0, SERC_BACCR;  
Q638W1, SERC_BACCZ;  Q5LDN9, SERC_BACFN;  Q64UR4, SERC_BACFR;  
Q9KDM4, SERC_BACHD;  Q6HGI0, SERC_BACHK;  Q5WHT9, SERC_BACSK;  
P80862, SERC_BACSU;  Q8A8L4, SERC_BACTN;  A6L5A6, SERC_BACV8;  
Q1LTL2, SERC_BAUCH;  Q7VR40, SERC_BLOFL;  Q492S5, SERC_BLOPB;  
Q2L2T1, SERC_BORA1;  Q7WGU2, SERC_BORBR;  Q7W5Z9, SERC_BORPA;  
A9IJI3, SERC_BORPD;  Q7VZG4, SERC_BORPE;  B8D9A2, SERC_BUCA5;  
P57397, SERC_BUCAI;  P81435, SERC_BUCAP;  B8D7K4, SERC_BUCAT;  
P59492, SERC_BUCBP;  Q057N5, SERC_BUCCC;  B1YV30, SERC_BURA4;  
Q1BY31, SERC_BURCA;  B1JXR6, SERC_BURCC;  A0K5L8, SERC_BURCH;  
B4EB45, SERC_BURCJ;  Q0BH96, SERC_BURCM;  Q39IG4, SERC_BURL3;  
A9ADV9, SERC_BURM1;  B2JF00, SERC_BURP8;  B2T637, SERC_BURPP;  
A4JCH1, SERC_BURVG;  P91856, SERC_CAEEL;  A8FKB5, SERC_CAMJ8;  
A7H543, SERC_CAMJD;  Q9PIH3, SERC_CAMJE;  A1VY45, SERC_CAMJJ;  
Q5HWE5, SERC_CAMJR;  B9KDM7, SERC_CAMLR;  Q7NVP1, SERC_CHRVO;  
A8AIH6, SERC_CITK8;  A4QCG9, SERC_CORGB;  B6J893, SERC_COXB1;  
B6J1E0, SERC_COXB2;  A9KCT6, SERC_COXBN;  A9NC17, SERC_COXBR;  
Q83E12, SERC_COXBU;  A7MES8, SERC_CROS8;  A9BM04, SERC_DELAS;  
B8FLC3, SERC_DESAA;  A9A0A5, SERC_DESOH;  Q6ALW3, SERC_DESPS;  
Q55CQ6, SERC_DICDI;  A5EV80, SERC_DICNV;  Q9VAN0, SERC_DROME;  
A7ZJZ6, SERC_ECO24;  B7UMZ3, SERC_ECO27;  B7MHL6, SERC_ECO45;  
B7LD99, SERC_ECO55;  Q8XEA7, SERC_ECO57;  B5YT41, SERC_ECO5E;  
B7NM68, SERC_ECO7I;  B7MS22, SERC_ECO81;  B7M835, SERC_ECO8A;  
C4ZQ33, SERC_ECOBW;  B1X847, SERC_ECODH;  A7ZYL0, SERC_ECOHS;  
A1A9I4, SERC_ECOK1;  Q0TJE6, SERC_ECOL5;  Q8FJB7, SERC_ECOL6;  
B1IW24, SERC_ECOLC;  P23721, SERC_ECOLI;  B7NAQ6, SERC_ECOLU;  
B6I8X9, SERC_ECOSE;  B1LJV7, SERC_ECOSM;  Q1RDV1, SERC_ECOUT;  
Q9X4H1, SERC_EDWI9;  A4W8S7, SERC_ENT38;  B2VC80, SERC_ERWT9;  
B7LN70, SERC_ESCF3;  C4L432, SERC_EXISA;  A5FH28, SERC_FLAJ1;  
A6GXC2, SERC_FLAPJ;  Q5L296, SERC_GEOKA;  Q7VLP0, SERC_HAEDU;  
P44336, SERC_HAEIN;  Q0I322, SERC_HAES1;  Q2SCF2, SERC_HAHCH;  
C4K3B1, SERC_HAMD5;  A9B6Q3, SERC_HERA2;  A4G865, SERC_HERAR;  
Q9Y617, SERC_HUMAN;  Q5QZ48, SERC_IDILO;  A6T1G7, SERC_JANMA;  
B5XY88, SERC_KLEP3;  A6T700, SERC_KLEP7;  B2GBS2, SERC_LACF3;  
A8YW78, SERC_LACH4;  Q9CHW5, SERC_LACLA;  A2RIS2, SERC_LACLM;  
Q031D5, SERC_LACLS;  Q88ZU5, SERC_LACPL;  C1D8N3, SERC_LARHH;  
Q5X5E7, SERC_LEGPA;  A5IBR0, SERC_LEGPC;  Q5ZVM2, SERC_LEGPH;  
Q5WWT0, SERC_LEGPL;  B0SCE2, SERC_LEPBA;  B0SKW4, SERC_LEPBP;  
Q72VI2, SERC_LEPIC;  Q8F930, SERC_LEPIN;  Q03W65, SERC_LEUMM;  
Q926T3, SERC_LISIN;  Q71VT6, SERC_LISMF;  Q8Y3L0, SERC_LISMO;  
B1HSU6, SERC_LYSSC;  Q65S80, SERC_MANSM;  A6VZ92, SERC_MARMS;  
Q8TNI1, SERC_METAC;  P52878, SERC_METBF;  Q8PT12, SERC_METMA;  
Q99K85, SERC_MOUSE;  A0QBI3, SERC_MYCA1;  P63515, SERC_MYCBO;  
O33062, SERC_MYCLE;  Q742L2, SERC_MYCPA;  A3Q635, SERC_MYCSJ;  
A1ULN4, SERC_MYCSK;  Q1B3G6, SERC_MYCSS;  P9WQ72, SERC_MYCTO;  
P9WQ73, SERC_MYCTU;  A1TF55, SERC_MYCVP;  Q1D2L9, SERC_MYXXD;  
Q5F7A0, SERC_NEIG1;  O34370, SERC_NEIMA;  P57007, SERC_NEIMB;  
A1KV48, SERC_NEIMF;  Q820S0, SERC_NITEU;  A1SEM0, SERC_NOCSJ;  
A6L9B7, SERC_PARD8;  P57881, SERC_PASMU;  Q6D400, SERC_PECAS;  
C6DF64, SERC_PECCP;  Q7N6D6, SERC_PHOLL;  Q6LPD9, SERC_PHOPR;  
A1VR16, SERC_POLNA;  Q12CL3, SERC_POLSJ;  B2RID6, SERC_PORG3;  
Q7MV30, SERC_PORGI;  B4ET24, SERC_PROMH;  A6V2Q8, SERC_PSEA7;  
B7V9J9, SERC_PSEA8;  Q02PX3, SERC_PSEAB;  Q9HZ66, SERC_PSEAE;  
Q1IDA2, SERC_PSEE4;  C3K6J5, SERC_PSEFS;  Q3ILA3, SERC_PSEHT;  
A4XTE7, SERC_PSEMY;  Q88M07, SERC_PSEPK;  Q885T5, SERC_PSESM;  
Q9RI02, SERC_PSEST;  Q4ZQ94, SERC_PSEU2;  P10658, SERC_RABIT;  
B2U882, SERC_RALPJ;  Q8Y0Z0, SERC_RALSO;  Q7UQL3, SERC_RHOBA;  
Q21Y51, SERC_RHOFT;  Q0S6R3, SERC_RHOJR;  C1ATN6, SERC_RHOOB;  
A1AWS0, SERC_RUTMC;  B5F159, SERC_SALA4;  A9MHX6, SERC_SALAR;  
Q57R24, SERC_SALCH;  B5FQ49, SERC_SALDC;  B5QYQ7, SERC_SALEP;  
B5R8J4, SERC_SALG2;  P62676, SERC_SALGL;  B4TD37, SERC_SALHS;  
B4T141, SERC_SALNS;  A9N7V7, SERC_SALPB;  C0PXU3, SERC_SALPC;  
B4TRT8, SERC_SALSV;  P62677, SERC_SALTI;  P55900, SERC_SALTY;  
Q10349, SERC_SCHPO;  A8GCH0, SERC_SERP5;  A1S6D1, SERC_SHEAM;  
B8EA90, SERC_SHEB2;  A3D4A1, SERC_SHEB5;  A6WNN5, SERC_SHEB8;  
A9L2Y2, SERC_SHEB9;  Q12MU6, SERC_SHEDO;  Q081U0, SERC_SHEFN;  
B0TT41, SERC_SHEHH;  Q8EEH2, SERC_SHEON;  A8H4A2, SERC_SHEPA;  
A4Y757, SERC_SHEPC;  B8CMG9, SERC_SHEPW;  A0KWN5, SERC_SHESA;  
A8FVN8, SERC_SHESH;  Q0HIX3, SERC_SHESM;  Q0HV09, SERC_SHESR;  
A1RJD3, SERC_SHESW;  B1KF45, SERC_SHEWM;  B2TUH4, SERC_SHIB3;  
Q31YU4, SERC_SHIBS;  Q32E24, SERC_SHIDS;  Q83LP3, SERC_SHIFL;  
Q3Z3L5, SERC_SHISS;  Q2NUB0, SERC_SODGM;  P52877, SERC_SPIOL;  
Q8E3Y3, SERC_STRA3;  B4SP45, SERC_STRM5;  B2FKF0, SERC_STRMK;  
Q8DSV3, SERC_STRMU;  A4W0D4, SERC_STRS2;  A3CPJ2, SERC_STRSV;  
A4VU42, SERC_STRSY;  Q5LYP0, SERC_STRT1;  Q5M3A4, SERC_STRT2;  
Q03JH6, SERC_STRTD;  B9DTW4, SERC_STRU0;  A0LK14, SERC_SYNFM;  
Q3SK88, SERC_THIDA;  A5CWI0, SERC_VESOH;  Q9KSU7, SERC_VIBCH;  
Q5E6F2, SERC_VIBF1;  B5FCJ8, SERC_VIBFM;  Q87QA3, SERC_VIBPA;  
Q8D900, SERC_VIBVU;  Q7MLH6, SERC_VIBVY;  Q8D268, SERC_WIGBR;  
Q8PLY7, SERC_XANAC;  Q3BUZ3, SERC_XANC5;  Q4UTC9, SERC_XANC8;  
B0RUW3, SERC_XANCB;  Q8PA97, SERC_XANCP;  Q2P354, SERC_XANOM;  
B2SJJ1, SERC_XANOP;  Q5H079, SERC_XANOR;  Q8RLW0, SERC_XENNA;  
Q9PB19, SERC_XYLFA;  Q87BU0, SERC_XYLFT;  P33330, SERC_YEAST;  
P19689, SERC_YERE8;  A7FJX0, SERC_YERP3;  Q1CA74, SERC_YERPA;  
B2KA22, SERC_YERPB;  Q8ZGB4, SERC_YERPE;  A9R7I1, SERC_YERPG;  
A4TN19, SERC_YERPP;  Q66CI9, SERC_YERPS;  B1JRE0, SERC_YERPY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.1.-
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