ENZYME entry: EC 2.6.1.81

Accepted Name
Succinylornithine transaminase.
Alternative Name(s)
N(2)-succinylornithine 5-aminotransferase.
SOAT.
Succinylornithine aminotransferase.
Reaction catalysed
N(2)-succinyl-L-ornithine + 2-oxoglutarate <=> N-succinyl-L-glutamate 5-semialdehyde + L-glutamate
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • Also acts on N(2)-acetyl-L-ornithine and L-ornithine, but more slowly.
  • In Pseudomonas aeruginosa, the arginine-inducible succinylornithine transaminase, EC 2.6.1.11 and EC 2.6.1.13 activities are catalyzed by the same enzyme, but this is not the case in all species.
  • This is the third enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine.
  • This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA.
  • The five enzymes involved in this pathway are EC 2.3.1.109, EC 3.5.3.23, EC 2.6.1.81, EC 1.2.1.71 and EC 3.5.1.96.
Cross-references
PROSITEPDOC00519
BRENDA2.6.1.81
EC2PDB2.6.1.81
ExplorEnz2.6.1.81
PRIAM enzyme-specific profiles2.6.1.81
KEGG Ligand Database for Enzyme Nomenclature2.6.1.81
IUBMB Enzyme Nomenclature2.6.1.81
IntEnz2.6.1.81
MEDLINEFind literature relating to 2.6.1.81
MetaCyc2.6.1.81
UniProtKB/Swiss-Prot
O30508, ARUC_PSEAE;  A8AHE0, ASTC_CITK8;  A7ZML6, ASTC_ECO24;  
B7USC9, ASTC_ECO27;  B7MAV9, ASTC_ECO45;  B7L6M2, ASTC_ECO55;  
Q8X598, ASTC_ECO57;  B5YQ35, ASTC_ECO5E;  B7NT29, ASTC_ECO7I;  
B7MVM7, ASTC_ECO81;  B7M1G0, ASTC_ECO8A;  C4ZZA4, ASTC_ECOBW;  
B1XGK9, ASTC_ECODH;  A8A0U0, ASTC_ECOHS;  A1ABS9, ASTC_ECOK1;  
Q0TH82, ASTC_ECOL5;  Q8FGZ9, ASTC_ECOL6;  B1IPI2, ASTC_ECOLC;  
P77581, ASTC_ECOLI;  B7N584, ASTC_ECOLU;  B6IBG8, ASTC_ECOSE;  
B1LDY3, ASTC_ECOSM;  Q1RB45, ASTC_ECOUT;  B7LQ44, ASTC_ESCF3;  
Q7N2G7, ASTC_PHOLL;  B5F846, ASTC_SALA4;  Q57PX9, ASTC_SALCH;  
B5FJD8, ASTC_SALDC;  B5QWJ0, ASTC_SALEP;  B5RB01, ASTC_SALG2;  
B4TGE0, ASTC_SALHS;  B4T3Z4, ASTC_SALNS;  Q5PHC8, ASTC_SALPA;  
A9N278, ASTC_SALPB;  C0Q6X9, ASTC_SALPC;  B5BA72, ASTC_SALPK;  
Q8Z6F9, ASTC_SALTI;  Q8ZPV2, ASTC_SALTY;  B2U3D0, ASTC_SHIB3;  
Q321P0, ASTC_SHIBS;  Q3Z295, ASTC_SHISS;  A1JS45, ASTC_YERE8;  
A7FIL6, ASTC_YERP3;  Q1C8B1, ASTC_YERPA;  Q8D0D7, ASTC_YERPE;  
A9QZ63, ASTC_YERPG;  Q66B21, ASTC_YERPS;  

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