ENZYME entry: EC 2.6.1.83

Accepted Name
LL-diaminopimelate aminotransferase.
Alternative Name(s)
LL-DAP aminotransferase.
LL-DAP-AT.
LL-diaminopimelate transaminase.
Reaction catalysed
LL-2,6-diaminoheptanedioate + 2-oxoglutarate <=> (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H(2)O
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • In vivo, the reaction occurs in the opposite direction to that shown above.
  • This is one of the final steps in the lysine biosynthesis pathway of plants (ranging from mosses to flowering plants).
  • Meso-diaminoheptanedioate, an isomer of LL-2,6-diaminoheptanedioate, and the structurally related compounds lysine and ornithine are not substrates.
  • 2-oxoglutarate cannot be replaced by oxaloacetate or pyruvate.
  • It is not yet known if the substrate of the biosynthetic reaction is the cyclic or acyclic form of tetrahydropyridine-2,6-dicarboxylate.
Cross-references
PROSITEPDOC00098
BRENDA2.6.1.83
EC2PDB2.6.1.83
ExplorEnz2.6.1.83
PRIAM enzyme-specific profiles2.6.1.83
KEGG Ligand Database for Enzyme Nomenclature2.6.1.83
IUBMB Enzyme Nomenclature2.6.1.83
IntEnz2.6.1.83
MEDLINEFind literature relating to 2.6.1.83
MetaCyc2.6.1.83
UniProtKB/Swiss-Prot
B0CDH5, DAPAT_ACAM1;  O66630, DAPAT_AQUAE;  Q93ZN9, DAPAT_ARATH;  
B6YRL2, DAPAT_AZOPC;  Q5LC03, DAPAT_BACFN;  Q64SY6, DAPAT_BACFR;  
Q8AAB8, DAPAT_BACTN;  A6L7E4, DAPAT_BACV8;  Q3AC10, DAPAT_CARHZ;  
Q5L6M0, DAPAT_CHLAB;  Q824A4, DAPAT_CHLCV;  Q253K9, DAPAT_CHLFF;  
Q9PK04, DAPAT_CHLMU;  Q9Z856, DAPAT_CHLPN;  B0B7W0, DAPAT_CHLT2;  
Q3KLW3, DAPAT_CHLTA;  B0BC25, DAPAT_CHLTB;  O84395, DAPAT_CHLTR;  
A9KJ19, DAPAT_CLOPH;  A3DK17, DAPAT_CLOTH;  B1WSG7, DAPAT_CYAA5;  
B8HJY4, DAPAT_CYAP4;  B7KL61, DAPAT_CYAP7;  B7JVL5, DAPAT_CYAP8;  
Q3Z8H5, DAPAT_DEHE1;  A5FRC5, DAPAT_DEHSB;  Q3ZXC8, DAPAT_DEHSC;  
C6BUK3, DAPAT_DESAD;  C0QFJ4, DAPAT_DESAH;  B1I544, DAPAT_DESAP;  
B8IZX8, DAPAT_DESDA;  Q30ZX9, DAPAT_DESDG;  Q18T09, DAPAT_DESHD;  
Q24S01, DAPAT_DESHY;  A8ZXV5, DAPAT_DESOH;  Q6AL81, DAPAT_DESPS;  
Q72BI1, DAPAT_DESVH;  B8DJJ6, DAPAT_DESVM;  A1VDD3, DAPAT_DESVV;  
C4Z4Y1, DAPAT_EUBE2;  C4ZG66, DAPAT_EUBR3;  B5EGX2, DAPAT_GEOBB;  
B3E933, DAPAT_GEOLS;  Q39Z65, DAPAT_GEOMG;  B9M384, DAPAT_GEOSF;  
Q74GT3, DAPAT_GEOSL;  C6E9Q7, DAPAT_GEOSM;  A5GD93, DAPAT_GEOUR;  
Q7NDX4, DAPAT_GLOVI;  B8CX89, DAPAT_HALOH;  B0TA38, DAPAT_HELMI;  
Q1MR87, DAPAT_LAWIP;  B0SEH8, DAPAT_LEPBA;  Q04UL5, DAPAT_LEPBJ;  
Q04YV8, DAPAT_LEPBL;  B0SMK7, DAPAT_LEPBP;  Q72NJ3, DAPAT_LEPIC;  
Q8F814, DAPAT_LEPIN;  Q58786, DAPAT_METJA;  Q6LX26, DAPAT_METMP;  
A5UN82, DAPAT_METS3;  Q2NFU1, DAPAT_METST;  O26158, DAPAT_METTH;  
B0JUM0, DAPAT_MICAN;  Q2RK33, DAPAT_MOOTA;  B2A250, DAPAT_NATTJ;  
B2J2U3, DAPAT_NOSP7;  Q10MQ2, DAPAT_ORYSJ;  A6L8U2, DAPAT_PARD8;  
Q6MDE0, DAPAT_PARUW;  Q3A1U5, DAPAT_PELCD;  A1ATI6, DAPAT_PELPD;  
A3PEY9, DAPAT_PROM0;  A2C4T7, DAPAT_PROM1;  A2CC97, DAPAT_PROM3;  
A9BCJ1, DAPAT_PROM4;  A2BYM6, DAPAT_PROM5;  Q318P3, DAPAT_PROM9;  
Q7VA14, DAPAT_PROMA;  Q7V4Z3, DAPAT_PROMM;  Q7UZZ3, DAPAT_PROMP;  
A2BT75, DAPAT_PROMS;  Q46IX2, DAPAT_PROMT;  Q31PY6, DAPAT_SYNE7;  
A0LEA5, DAPAT_SYNFM;  Q2JS04, DAPAT_SYNJA;  Q2JLL9, DAPAT_SYNJB;  
B1XKF6, DAPAT_SYNP2;  Q5N492, DAPAT_SYNP6;  A5GIN1, DAPAT_SYNPW;  
Q7U4C3, DAPAT_SYNPX;  A5GW23, DAPAT_SYNR3;  Q0ID68, DAPAT_SYNS3;  
Q3AW44, DAPAT_SYNS9;  Q3AMU5, DAPAT_SYNSC;  Q55828, DAPAT_SYNY3;  
Q8DH57, DAPAT_THEEB;  Q10ZC3, DAPAT_TRIEI;  Q3MAL4, DAPT1_ANAVT;  
Q8YM38, DAPT1_NOSS1;  Q3MDN5, DAPT2_ANAVT;  Q8YP73, DAPT2_NOSS1;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.1.-
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