ENZYME entry: EC 2.6.1.84

Accepted Name
Arginine--pyruvate transaminase.
Alternative Name(s)
Arginine:pyruvate transaminase.
Reaction catalysed
L-arginine + pyruvate <=> 5-guanidino-2-oxopentanoate + L-alanine
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • While L-arginine is the best substrate, the enzyme exhibits broad substrate specificity, with L-lysine, L-methionine, L-leucine, L-ornithine and L-glutamine also able to act as substrates, but more slowly.
  • Pyruvate cannot be replaced by 2-oxoglutarate as amino-group acceptor.
  • This is the first catalytic enzyme of the arginine transaminase pathway for L-arginine utilization in Pseudomonas aeruginosa.
  • This pathway is only used when the major route of arginine catabolism, i.e. the arginine succinyltransferase pathway, is blocked.
Cross-references
BRENDA2.6.1.84
EC2PDB2.6.1.84
ExplorEnz2.6.1.84
PRIAM enzyme-specific profiles2.6.1.84
KEGG Ligand Database for Enzyme Nomenclature2.6.1.84
IUBMB Enzyme Nomenclature2.6.1.84
IntEnz2.6.1.84
MEDLINEFind literature relating to 2.6.1.84
MetaCyc2.6.1.84
UniProtKB/Swiss-Prot
Q9HUI9, ARUH_PSEAE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.1.-
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