ENZYME

ENZYME entry: EC 2.6.1.86

Accepted Name

2-amino-4-deoxychorismate synthase.

Alternative Name(s)

2-amino-2-deoxyisochorismate synthase.

ADIC synthase.

Reaction catalysed

(2S)-2-amino-4-deoxychorismate + L-glutamate <=> chorismate + L-glutamine

Cofactor(s)

Magnesium.

Comment(s)

The reaction occurs in the reverse direction to that shown above.
In contrast to most anthranilate-synthase I (ASI) homologs, this enzyme is not inhibited by tryptophan.
In Streptomyces globisporus, the sequential action of this enzyme and EC 1.3.99.24, 2-amino-4-deoxychorismate dehydrogenase, leads to the formation of the benzoxazolinate moiety of the enediyne antitumor antibiotic C-1027.
In certain Pseudomonads the enzyme participates in the biosynthesis of phenazine, a precursor for several compounds with antibiotic activity.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature