ENZYME entry: EC 2.7.1.134

Accepted Name
Inositol-tetrakisphosphate 1-kinase.
Alternative Name(s)
1D-myo-inositol-tetrakisphosphate 1-kinase.
1D-myo-inositol-trisphosphate 5-kinase.
1D-myo-inositol-trisphosphate 6-kinase.
Inositol-trisphosphate 5-kinase.
Inositol-trisphosphate 6-kinase.
Reaction catalysed
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate <=> ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
Comment(s)
  • This enzyme also phosphorylates Ins(1,3,4)P(3) on O-5 and O-6.
  • The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP.
  • It can also catalyze an isomerization between Ins(1,3,4,5)P(4) and Ins(1,3,4,6)P(4) in the presence of ADP.
  • Formerly EC 2.7.1.133 and EC 2.7.1.139.
Cross-references
PROSITEPDOC50975
BRENDA2.7.1.134
EC2PDB2.7.1.134
ExplorEnz2.7.1.134
PRIAM enzyme-specific profiles2.7.1.134
KEGG Ligand Database for Enzyme Nomenclature2.7.1.134
IUBMB Enzyme Nomenclature2.7.1.134
IntEnz2.7.1.134
MEDLINEFind literature relating to 2.7.1.134
MetaCyc2.7.1.134
UniProtKB/Swiss-Prot
Q9SBA5, ITPK1_ARATH;  P0C0T1, ITPK1_BOVIN;  Q5F480, ITPK1_CHICK;  
Q7ZU91, ITPK1_DANRE;  Q9XYQ1, ITPK1_ENTHI;  Q13572, ITPK1_HUMAN;  
Q84Y01, ITPK1_MAIZE;  Q8BYN3, ITPK1_MOUSE;  A2Z4C5, ITPK1_ORYSI;  
Q33BI9, ITPK1_ORYSJ;  Q7SY78, ITPK1_XENLA;  O81893, ITPK2_ARATH;  
B8AJL9, ITPK2_ORYSI;  Q10PL5, ITPK2_ORYSJ;  Q9SUG3, ITPK3_ARATH;  
B8AR41, ITPK3_ORYSI;  Q75GI4, ITPK3_ORYSJ;  A2X4M8, ITPK4_ORYSI;  
Q6K7B8, ITPK4_ORYSJ;  A0JJZ6, ITPK5_ORYSI;  Q7XBW0, ITPK5_ORYSJ;  
B8BDK0, ITPK6_ORYSI;  Q0J0B2, ITPK6_ORYSJ;  

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