ENZYME entry: EC 2.7.1.151

Accepted Name
Inositol-polyphosphate multikinase.
Alternative Name(s)
Inositol polyphosphate 6-/3-/5-kinase.
IP3/IP4 6-/3-kinase.
IP3/IP4 dual-specificity 6-/3-kinase.
IpK2.
Reaction catalysed
2 ATP + 1D-myo-inositol 1,4,5-trisphosphate <=> 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
Comment(s)
  • This enzyme also phosphorylates Ins(1,4,5)P(3) to Ins(1,3,4,5)P(4), Ins(1,3,4,5)P(4) to Ins(1,3,4,5,6)P(5), and Ins(1,3,4,5,6)P(4) to Ins(PP)P(4), isomer unknown.
  • The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P(4) and Ins(1,2,3,4,6)P(5) at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP(6)), respectively.
  • Yeast produces InsP(6) from Ins(1,4,5)P(3) by the actions of this enzyme and EC 2.7.1.158.
Cross-references
BRENDA2.7.1.151
EC2PDB2.7.1.151
ExplorEnz2.7.1.151
PRIAM enzyme-specific profiles2.7.1.151
KEGG Ligand Database for Enzyme Nomenclature2.7.1.151
IUBMB Enzyme Nomenclature2.7.1.151
IntEnz2.7.1.151
MEDLINEFind literature relating to 2.7.1.151
MetaCyc2.7.1.151
UniProtKB/Swiss-Prot
A2X5H5, IPK2_ORYSI;  Q6H545, IPK2_ORYSJ;  Q9LY23, IPMKA_ARATH;  
Q9FLT2, IPMKB_ARATH;  Q8NFU5, IPMK_HUMAN;  Q7TT16, IPMK_MOUSE;  
Q99NI4, IPMK_RAT;  P07250, IPMK_YEAST;  

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