ENZYME entry: EC 2.7.1.159

Accepted Name
Inositol-1,3,4-trisphosphate 5/6-kinase.
Alternative Name(s)
Inositol trisphosphate 5/6-kinase.
Ins(1,3,4)P(3) 5/6-kinase.
IP56K.
Reaction catalysed
  • ATP + 1D-myo-inositol 1,3,4-trisphosphate <=> ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
  • ATP + 1D-myo-inositol 1,3,4-trisphosphate <=> ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
Comment(s)
  • In humans, this enzyme, along with EC 2.7.1.127, EC 2.7.1.140 and EC 2.7.1.158 is involved in the production of inositol hexakisphosphate (InsP(6)).
  • InsP(6) is involved in many cellular processes, including mRNA export from the nucleus.
  • Yeast do not have this enzyme, so produce InsP(6) from Ins(1,4,5)P(3) by the actions of EC 2.7.1.151 and EC 2.7.1.158.
Cross-references
PROSITEPDOC50975
BRENDA2.7.1.159
EC2PDB2.7.1.159
ExplorEnz2.7.1.159
PRIAM enzyme-specific profiles2.7.1.159
KEGG Ligand Database for Enzyme Nomenclature2.7.1.159
IUBMB Enzyme Nomenclature2.7.1.159
IntEnz2.7.1.159
MEDLINEFind literature relating to 2.7.1.159
MetaCyc2.7.1.159
UniProtKB/Swiss-Prot
Q9SBA5, ITPK1_ARATH;  P0C0T1, ITPK1_BOVIN;  Q5F480, ITPK1_CHICK;  
Q7ZU91, ITPK1_DANRE;  Q9XYQ1, ITPK1_ENTHI;  Q13572, ITPK1_HUMAN;  
Q84Y01, ITPK1_MAIZE;  Q8BYN3, ITPK1_MOUSE;  A2Z4C5, ITPK1_ORYSI;  
Q33BI9, ITPK1_ORYSJ;  Q7SY78, ITPK1_XENLA;  O81893, ITPK2_ARATH;  
B8AJL9, ITPK2_ORYSI;  Q10PL5, ITPK2_ORYSJ;  Q9SUG3, ITPK3_ARATH;  
B8AR41, ITPK3_ORYSI;  Q75GI4, ITPK3_ORYSJ;  O80568, ITPK4_ARATH;  
A2X4M8, ITPK4_ORYSI;  Q6K7B8, ITPK4_ORYSJ;  A0JJZ6, ITPK5_ORYSI;  
Q7XBW0, ITPK5_ORYSJ;  B8BDK0, ITPK6_ORYSI;  Q0J0B2, ITPK6_ORYSJ;  

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