ENZYME entry: EC 2.7.1.169

Accepted Name
Pantoate kinase.
Reaction catalysed
ATP + (R)-pantoate <=> ADP + (R)-4-phosphopantoate
Comment(s)
  • The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein.
  • In bacteria and eukaryotes this conversion is performed by condensation with beta-alanine, followed by phosphorylation (EC 6.3.2.1 and EC 2.7.1.33, respectively).
  • In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with beta-alanine.
Cross-references
BRENDA2.7.1.169
EC2PDB2.7.1.169
ExplorEnz2.7.1.169
PRIAM enzyme-specific profiles2.7.1.169
KEGG Ligand Database for Enzyme Nomenclature2.7.1.169
IUBMB Enzyme Nomenclature2.7.1.169
IntEnz2.7.1.169
MEDLINEFind literature relating to 2.7.1.169
MetaCyc2.7.1.169
UniProtKB/Swiss-Prot
Q58379, POK_METJA;  Q5JHF1, POK_PYRKO;  

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