ENZYME entry: EC 2.7.1.171
| Accepted Name |
|---|
| Protein-fructosamine 3-kinase.
|
| Alternative Name(s) |
|---|
| Fructosamine 3-kinase. |
| Reaction catalysed |
|---|
| ATP + [protein]-N(6)-D-fructosyl-L-lysine <=> ADP + [protein]-N(6)-(3-O-phospho-D-fructosyl)-L-lysine |
| Comment(s) |
|---|
- Nonenzymatic glycation is an important factor in the pathogenesis of
diabetic complications.
- Key early intermediates in this process are fructosamines, such as
[protein]-N(6)-D-fructosyl-L-lysine.
- Fructosamine-3-kinase is part of an ATP-dependent system for removing
carbohydrates from nonenzymatically glycated proteins.
- The phosphorylation destablilizes the [protein]-N(6)-D-fructosyl-L-
lysine adduct and leads to its spontaneous decomposition.
- Cf. EC 2.7.1.172.
|
| Cross-references |
|---|
| BRENDA | 2.7.1.171 |
| EC2PDB | 2.7.1.171 |
| ExplorEnz | 2.7.1.171 |
| PRIAM enzyme-specific profiles | 2.7.1.171 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.171 |
| IUBMB Enzyme Nomenclature | 2.7.1.171 |
| IntEnz | 2.7.1.171 |
| MEDLINE | Find literature relating to 2.7.1.171 |
| MetaCyc | 2.7.1.171 |
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