ENZYME entry: EC 2.7.1.174

Accepted Name
Diacylglycerol kinase (CTP).
Alternative Name(s)
CTP-dependent diacylglycerol kinase.
DAG kinase.
Diacylglycerol kinase (CTP dependent).
Diglyceride kinase.
Reaction catalysed
CTP + 1,2-diacyl-sn-glycerol <=> CDP + 1,2-diacyl-sn-glycerol 3-phosphate
Cofactor(s)
Mg(2+) or Ca(2+).
Comment(s)
  • Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol.
  • Unlike the diacylglycerol kinases from bacteria, plants, and animals (cf. EC 2.7.1.107), the enzyme from Saccharomyces cerevisiae utilizes CTP.
  • The enzyme can also use dCTP, but not ATP, GTP or UTP.
  • Formerly EC 2.7.1.n5.
Cross-references
BRENDA2.7.1.174
EC2PDB2.7.1.174
ExplorEnz2.7.1.174
PRIAM enzyme-specific profiles2.7.1.174
KEGG Ligand Database for Enzyme Nomenclature2.7.1.174
IUBMB Enzyme Nomenclature2.7.1.174
IntEnz2.7.1.174
MEDLINEFind literature relating to 2.7.1.174
MetaCyc2.7.1.174
UniProtKB/Swiss-Prot
Q753I3, DGK1_ASHGO;  P87170, DGK1_SCHPO;  Q12382, DGK1_YEAST;  

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