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ENZYME entry: EC 2.7.1.183

Accepted Name
Glycoprotein-mannosyl O(6)-kinase.
Alternative Name(s)
Protein O-mannose kinase.
Reaction catalysed
ATP + O(3)-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl/L-seryl-[protein] <=> ADP + O(3)-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-(6-phospho)mannosyl)-L-threonyl/L-seryl-[protein]
Comment(s)
In humans this phosphorylated trisaccharide is attached to an L-threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and is important for its activity.
Cross-references
BRENDA2.7.1.183
EC2PDB2.7.1.183
ExplorEnz2.7.1.183
PRIAM enzyme-specific profiles2.7.1.183
KEGG Ligand Database for Enzyme Nomenclature2.7.1.183
IUBMB Enzyme Nomenclature2.7.1.183
IntEnz2.7.1.183
MEDLINEFind literature relating to 2.7.1.183
MetaCyc2.7.1.183
UniProtKB/Swiss-Prot
Q5U3W1, SG196_DANRE;  Q9H5K3, SG196_HUMAN;  Q95JJ0, SG196_MACFA;  
Q4V8A9, SG196_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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