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ENZYME entry: EC 220.127.116.11
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|Aminoglycoside (2'') kinase.|
|GTP + gentamicin <=> GDP + gentamicin 2''-phosphate|
- This bacterial enzyme phosphorylates many 4,6-disubstituted
aminoglycoside antibiotics that have a hydroxyl group at position
2'', including kanamycin A, kanamycin B, tobramycin, dibekacin,
arbekacin, amikacin, gentamicin C, sisomicin and netilmicin.
- In most, but not all, cases the phosphorylation confers resistance
against the antibiotic.
- Some forms of the enzyme use ATP as a phosphate donor in appreciable
- The enzyme is often found as a bifunctional enzyme that also
catalyzes 6'-aminoglycoside N-acetyltransferase activity.
- The bifunctional enzyme is the most clinically important
aminoglycoside-modifying enzyme in Gram-positive bacteria,
responsible for high-level resistance in both Enterococci and
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
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