ENZYME entry: EC 2.7.1.202

Accepted Name
Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase.
Alternative Name(s)
Fructose PTS permease.
Reaction catalysed
[Protein]-N(pi)-phospho-L-histidine + D-fructose(Side 1) <=> [protein]-L-histidine + D-fructose 1-phosphate(Side 2)
Comment(s)
  • This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS).
  • The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it.
  • The phosphate donor, which is shared among the different systems, is usually a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9.
  • The enzyme from the bacterium Escherichia coli is an exception, since it is phosphorylated directly by EC 2.7.3.9.
  • The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
  • Formerly EC 2.7.1.69.
Cross-references
PROSITEPDOC00795
BRENDA2.7.1.202
EC2PDB2.7.1.202
ExplorEnz2.7.1.202
PRIAM enzyme-specific profiles2.7.1.202
KEGG Ligand Database for Enzyme Nomenclature2.7.1.202
IUBMB Enzyme Nomenclature2.7.1.202
IntEnz2.7.1.202
MEDLINEFind literature relating to 2.7.1.202
MetaCyc2.7.1.202
UniProtKB/Swiss-Prot
P71012, PTF3A_BACSU;  P47308, PTF3A_MYCGE;  P75039, PTF3A_MYCPN;  
P69812, PTFAH_ECO57;  P69811, PTFAH_ECOLI;  P44715, PTFAH_HAEIN;  
Q8Z591, PTFAH_SALTI;  P17127, PTFAH_SALTY;  P23388, PTFAX_RHOCA;  
P45597, PTFAX_XANCP;  P26379, PTFA_BACSU;  D4GYE4, PTFA_HALVD;  
P69810, PTFB1_ECO57;  P69809, PTFB1_ECOL6;  P69808, PTFB1_ECOLI;  
Q821A9, PTFB1_SHIFL;  P69818, PTFB2_ECO57;  P69817, PTFB2_ECOL6;  
P69816, PTFB2_ECOLI;  P69819, PTFB2_SHIFL;  P32676, PTFB3_ECOLI;  
P20966, PTFBC_ECOLI;  P44714, PTFBC_HAEIN;  P23387, PTFBC_RHOCA;  
P23355, PTFBC_XANCP;  P26380, PTFB_BACSU;  D4GYE1, PTFB_HALVD;  
P32155, PTFLA_ECOLI;  P32154, PTFLB_ECOLI;  P77439, PTFX1_ECOLI;  
P32670, PTFX2_ECOLI;  Q8XBQ8, PTFX_ECO57;  Q8FFD8, PTFX_ECOL6;  
Q83QP3, PTFX_SHIFL;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
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