ENZYME entry: EC 2.7.1.26

Accepted Name
Riboflavin kinase.
Alternative Name(s)
Flavokinase.
RFK.
Reaction catalysed
ATP + riboflavin <=> ADP + FMN
Cofactor(s)
Mg(2+) or Zn(2+) or Mn(2+).
Comment(s)
  • The cofactors FMN and FAD participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin B(6), vitamin B12 and folates.
  • While monofunctional riboflavin kinase is found in eukaryotes, some bacteria have a bifunctional enzyme that exhibits both this activity and that of EC 2.7.7.2.
  • In Bacillus subtilis, ATP can be replaced by other phosphate donors but with decreasing enzyme activity in the order ATP > dATP > CTP > UTP.
Cross-references
BRENDA2.7.1.26
EC2PDB2.7.1.26
ExplorEnz2.7.1.26
PRIAM enzyme-specific profiles2.7.1.26
KEGG Ligand Database for Enzyme Nomenclature2.7.1.26
IUBMB Enzyme Nomenclature2.7.1.26
IntEnz2.7.1.26
MEDLINEFind literature relating to 2.7.1.26
MetaCyc2.7.1.26
UniProtKB/Swiss-Prot
Q84MD8, FHYRK_ARATH;  Q7NBZ0, MNMA_MYCGA;  P54575, RIBC_BACSU;  
P57250, RIBF_BUCAI;  Q8K9Z1, RIBF_BUCAP;  Q59263, RIBF_CORAM;  
P0AG42, RIBF_ECO57;  P0AG41, RIBF_ECOL6;  P0AG40, RIBF_ECOLI;  
A4IT50, RIBF_GEOTN;  P44957, RIBF_HAEIN;  P47391, RIBF_MYCGE;  
P75587, RIBF_MYCPN;  P22990, RIBF_PSEFL;  O84990, RIBF_RHOOP;  
P0AG43, RIBF_SHIFL;  P73651, RIBF_SYNY3;  P94465, RIBR_BACSU;  
Q75DY2, RIFK_ASHGO;  A1C603, RIFK_ASPCL;  Q4WHD2, RIFK_ASPFU;  
A2QFH1, RIFK_ASPNC;  Q2UMM4, RIFK_ASPOR;  Q0CHR1, RIFK_ASPTN;  
Q6FM49, RIFK_CANGA;  P0C5D9, RIFK_CHAGB;  O76206, RIFK_DROME;  
Q5AW61, RIFK_EMENI;  Q969G6, RIFK_HUMAN;  Q6CT57, RIFK_KLULA;  
A5E1A0, RIFK_LODEL;  A4QQ05, RIFK_MAGO7;  Q8CFV9, RIFK_MOUSE;  
A1DG00, RIFK_NEOFI;  Q6M923, RIFK_NEUCR;  A5DAH9, RIFK_PICGU;  
A3M0C9, RIFK_PICST;  O74866, RIFK_SCHPO;  Q6CG11, RIFK_YARLI;  
Q03778, RIFK_YEAST;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-