ID   2.7.1.91
DE   sphingosine kinase.
AN   dihydrosphingosine kinase.
AN   sphinganine kinase.
AN   sphingoid base kinase.
CA   a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+).
CC   -!- The enzyme is involved in the production of sphingolipid metabolites.
CC   -!- It phosphorylates various sphingoid long-chain bases, such as
CC       sphingosine, D-erythro-dihydrosphingosine (sphinganine),
CC       phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine,
CC       4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo-
CC       dihydrosphingosine.
CC   -!- The exact substrate range depends on the species.
DR   O14159, LCB4_SCHPO ;  Q12246, LCB4_YEAST ;  Q06147, LCB5_YEAST ;
DR   Q8L7L1, SPHK1_ARATH;  Q18425, SPHK1_CAEEL;  Q9NYA1, SPHK1_HUMAN;
DR   Q8CI15, SPHK1_MOUSE;  Q91V26, SPHK1_RAT  ;  F2Y4A3, SPHK2_ARATH;
DR   Q9NRA0, SPHK2_HUMAN;  Q9JIA7, SPHK2_MOUSE;  Q86KF9, SPHKA_DICDI;
DR   Q6B516, SPHKB_DICDI;
//