ENZYME entry: EC 2.7.10.1

Accepted Name
Receptor protein-tyrosine kinase.
Alternative Name(s)
Receptor protein tyrosine kinase.
Reaction catalysed
ATP + a [protein]-L-tyrosine <=> ADP + a [protein]-L-tyrosine phosphate
Comment(s)
  • The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans.
  • In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
  • Formerly EC 2.7.1.112.
Cross-references
PROSITEPDOC00100
BRENDA2.7.10.1
EC2PDB2.7.10.1
ExplorEnz2.7.10.1
PRIAM enzyme-specific profiles2.7.10.1
KEGG Ligand Database for Enzyme Nomenclature2.7.10.1
IUBMB Enzyme Nomenclature2.7.10.1
IntEnz2.7.10.1
MEDLINEFind literature relating to 2.7.10.1
MetaCyc2.7.10.1
UniProtKB/Swiss-Prot
P13368, 7LESS_DROME;  P20806, 7LESS_DROVI;  Q54N73, 7TMK1_DICDI;  
Q9UM73, ALK_HUMAN;  P97793, ALK_MOUSE;  Q94F62, BAK1_ARATH;  
O22476, BRI1_ARATH;  Q9LJF3, BRL3_ARATH;  Q9VBW3, CAD96_DROME;  
P79750, CSF11_TAKRU;  Q8UVR8, CSF12_TAKRU;  Q9I8N6, CSF1R_DANRE;  
P13369, CSF1R_FELCA;  P07333, CSF1R_HUMAN;  P09581, CSF1R_MOUSE;  
Q00495, CSF1R_RAT;  Q08345, DDR1_HUMAN;  Q03146, DDR1_MOUSE;  
Q7YR43, DDR1_PANTR;  Q63474, DDR1_RAT;  Q16832, DDR2_HUMAN;  
Q62371, DDR2_MOUSE;  P0CY46, EGFR_APIME;  P13387, EGFR_CHICK;  
P04412, EGFR_DROME;  P00533, EGFR_HUMAN;  P55245, EGFR_MACMU;  
Q01279, EGFR_MOUSE;  Q10656, EGL15_CAEEL;  O13148, EPA4A_DANRE;  
Q91845, EPA4A_XENLA;  Q91694, EPA4B_XENLA;  Q91571, EPB1A_XENLA;  
Q91736, EPB1B_XENLA;  P21709, EPHA1_HUMAN;  Q60750, EPHA1_MOUSE;  
P29317, EPHA2_HUMAN;  Q1KL86, EPHA2_MACFA;  Q03145, EPHA2_MOUSE;  
P29318, EPHA3_CHICK;  O13146, EPHA3_DANRE;  P29320, EPHA3_HUMAN;  
P29319, EPHA3_MOUSE;  O08680, EPHA3_RAT;  Q07496, EPHA4_CHICK;  
P54764, EPHA4_HUMAN;  Q03137, EPHA4_MOUSE;  P54755, EPHA5_CHICK;  
P54756, EPHA5_HUMAN;  Q60629, EPHA5_MOUSE;  P54757, EPHA5_RAT;  
Q9UF33, EPHA6_HUMAN;  Q62413, EPHA6_MOUSE;  P54758, EPHA6_RAT;  
O42422, EPHA7_CHICK;  Q15375, EPHA7_HUMAN;  Q61772, EPHA7_MOUSE;  
P54759, EPHA7_RAT;  P29322, EPHA8_HUMAN;  O09127, EPHA8_MOUSE;  
P29321, EPHA8_RAT;  Q5JZY3, EPHAA_HUMAN;  Q8BYG9, EPHAA_MOUSE;  
Q07494, EPHB1_CHICK;  P54762, EPHB1_HUMAN;  Q8CBF3, EPHB1_MOUSE;  
P09759, EPHB1_RAT;  P28693, EPHB2_CHICK;  Q90344, EPHB2_COTJA;  
P29323, EPHB2_HUMAN;  P54763, EPHB2_MOUSE;  Q07498, EPHB3_CHICK;  
O13147, EPHB3_DANRE;  P54753, EPHB3_HUMAN;  P54754, EPHB3_MOUSE;  
Q91735, EPHB3_XENLA;  P54760, EPHB4_HUMAN;  P54761, EPHB4_MOUSE;  
Q07497, EPHB5_CHICK;  O18735, ERBB2_CANFA;  P04626, ERBB2_HUMAN;  
Q60553, ERBB2_MESAU;  P70424, ERBB2_MOUSE;  P06494, ERBB2_RAT;  
P21860, ERBB3_HUMAN;  Q61526, ERBB3_MOUSE;  Q5RB22, ERBB3_PONAB;  
Q62799, ERBB3_RAT;  Q15303, ERBB4_HUMAN;  Q61527, ERBB4_MOUSE;  
Q62956, ERBB4_RAT;  P00534, ERBB_ALV;  P00535, ERBB_AVIER;  
P11273, ERBB_AVIEU;  P21804, FGFR1_CHICK;  Q07407, FGFR1_DROME;  
Q8MY86, FGFR1_DUGJA;  P11362, FGFR1_HUMAN;  P16092, FGFR1_MOUSE;  
Q91285, FGFR1_PLEWA;  Q04589, FGFR1_RAT;  P22182, FGFR1_XENLA;  
P18461, FGFR2_CHICK;  Q8JG38, FGFR2_DANRE;  Q09147, FGFR2_DROME;  
Q8MY85, FGFR2_DUGJA;  P21802, FGFR2_HUMAN;  P21803, FGFR2_MOUSE;  
Q91147, FGFR2_NOTVI;  Q91286, FGFR2_PLEWA;  Q03364, FGFR2_XENLA;  
P18460, FGFR3_CHICK;  Q9I8X3, FGFR3_DANRE;  P22607, FGFR3_HUMAN;  
Q61851, FGFR3_MOUSE;  Q91287, FGFR3_PLEWA;  O42127, FGFR3_XENLA;  
Q90330, FGFR4_COTCO;  Q90413, FGFR4_DANRE;  P22455, FGFR4_HUMAN;  
Q03142, FGFR4_MOUSE;  Q91288, FGFR4_PLEWA;  Q498D6, FGFR4_RAT;  
Q91743, FGFR4_XENLA;  Q4H3K6, FGFR_CIOIN;  Q95YM9, FGFR_HALRO;  
Q86PM4, FGFR_HYDVU;  Q26614, FGFR_STRPU;  Q90Z00, FGR1A_DANRE;  
P36888, FLT3_HUMAN;  Q00342, FLT3_MOUSE;  Q25197, HTK7_HYDVU;  
Q05688, IGF1R_BOVIN;  P08069, IGF1R_HUMAN;  Q60751, IGF1R_MOUSE;  
Q29000, IGF1R_PIG;  P24062, IGF1R_RAT;  O73798, IGF1R_XENLA;  
O02466, ILPR_BRALA;  P14617, INSRR_CAVPO;  P14616, INSRR_HUMAN;  
Q9WTL4, INSRR_MOUSE;  Q64716, INSRR_RAT;  Q93105, INSR_AEDAE;  
Q968Y9, INSR_CAEEL;  P09208, INSR_DROME;  P06213, INSR_HUMAN;  
Q28516, INSR_MACMU;  P15208, INSR_MOUSE;  P15127, INSR_RAT;  
Q9PVZ4, INSR_XENLA;  P00545, KFMS_FSVMD;  P34891, KIN15_CAEEL;  
P34892, KIN16_CAEEL;  Q8JFR5, KITA_DANRE;  P43481, KIT_BOVIN;  
Q76II0, KIT_CALJA;  O97799, KIT_CANFA;  Q28317, KIT_CAPHI;  
Q08156, KIT_CHICK;  Q28889, KIT_FELCA;  P04048, KIT_FSVHZ;  
P10721, KIT_HUMAN;  P05532, KIT_MOUSE;  Q2HWD6, KIT_PIG;  
Q8AXC6, KIT_TAKRU;  Q91909, KIT_XENLA;  P24348, LET23_CAEEL;  
P29376, LTK_HUMAN;  P08923, LTK_MOUSE;  Q12866, MERTK_HUMAN;  
Q60805, MERTK_MOUSE;  P57097, MERTK_RAT;  Q07DV8, MET_AOTNA;  
Q00PJ8, MET_ATEAB;  Q09YL1, MET_ATEGE;  Q769I5, MET_BOVIN;  
Q2QLG5, MET_CALJA;  Q2QLC0, MET_CALMO;  Q75ZY9, MET_CANFA;  
Q2IBA6, MET_CHLAE;  Q07DZ1, MET_COLGU;  Q07E48, MET_DASNO;  
A1X150, MET_ECHTE;  Q2IBG7, MET_EULMM;  A0M8S8, MET_FELCA;  
Q2IBF2, MET_GORGO;  Q2QLA9, MET_HORSE;  P08581, MET_HUMAN;  
Q108U6, MET_LOXAF;  Q2QL89, MET_MICMU;  P16056, MET_MOUSE;  
Q09YK0, MET_MUNMU;  Q07E24, MET_MUSPF;  Q07E37, MET_NEONE;  
Q07DY1, MET_NOMLE;  Q07E01, MET_ORNAN;  Q2QLH6, MET_OTOGA;  
Q2QLF1, MET_PANTR;  A0M8R7, MET_PAPAN;  Q2QLE0, MET_PIG;  
Q2IBD8, MET_PONAB;  Q09YN5, MET_RABIT;  P97523, MET_RAT;  
Q2IBC0, MET_RHIFE;  Q09YH7, MET_SAIBB;  Q09YI9, MET_SHEEP;  
Q25410, MIPR_LYMST;  Q8AXY6, MUSK_CHICK;  O15146, MUSK_HUMAN;  
Q61006, MUSK_MOUSE;  Q62838, MUSK_RAT;  Q91009, NTRK1_CHICK;  
P04629, NTRK1_HUMAN;  Q3UFB7, NTRK1_MOUSE;  P35739, NTRK1_RAT;  
Q91987, NTRK2_CHICK;  Q16620, NTRK2_HUMAN;  P15209, NTRK2_MOUSE;  
Q63604, NTRK2_RAT;  Q91044, NTRK3_CHICK;  Q16288, NTRK3_HUMAN;  
Q5IFJ9, NTRK3_MACFA;  Q6VNS1, NTRK3_MOUSE;  Q5IS37, NTRK3_PANTR;  
P24786, NTRK3_PIG;  Q03351, NTRK3_RAT;  Q5IS82, NTRK3_SAIBB;  
Q9PUF6, PGFRA_CHICK;  Q9DE49, PGFRA_DANRE;  P16234, PGFRA_HUMAN;  
P26618, PGFRA_MOUSE;  P20786, PGFRA_RAT;  Q8AXC7, PGFRA_TAKRU;  
P26619, PGFRA_XENLA;  Q6QNF3, PGFRB_CANFA;  P09619, PGFRB_HUMAN;  
P05622, PGFRB_MOUSE;  Q05030, PGFRB_RAT;  P79749, PGFRB_TAKRU;  
P07949, RET_HUMAN;  P35546, RET_MOUSE;  G3V9H8, RET_RAT;  
P47735, RLK5_ARATH;  Q9LIG2, RLK6_ARATH;  Q9FN94, RLK7_ARATH;  
Q04912, RON_HUMAN;  Q62190, RON_MOUSE;  Q24488, ROR1_DROME;  
Q01973, ROR1_HUMAN;  Q9Z139, ROR1_MOUSE;  Q9V6K3, ROR2_DROME;  
Q01974, ROR2_HUMAN;  Q9Z138, ROR2_MOUSE;  P08941, ROS1_CHICK;  
P08922, ROS1_HUMAN;  Q78DX7, ROS1_MOUSE;  Q63132, ROS1_RAT;  
P00529, ROS_AVISU;  P42159, RTK2_GEOCY;  Q27324, RYK1_DROME;  
Q9V422, RYK2_DROME;  P33497, RYK_AVIR3;  P34925, RYK_HUMAN;  
Q01887, RYK_MOUSE;  Q9SKB2, SBIR1_ARATH;  Q94AG2, SERK1_ARATH;  
Q9SKG5, SERK4_ARATH;  Q06805, TIE1_BOVIN;  O73792, TIE1_DANRE;  
P35590, TIE1_HUMAN;  Q06806, TIE1_MOUSE;  Q06807, TIE2_BOVIN;  
O73791, TIE2_DANRE;  Q02763, TIE2_HUMAN;  Q02858, TIE2_MOUSE;  
P18475, TORSO_DROME;  O76997, TRK1_LYMST;  Q98949, TYRO3_CHICK;  
Q9YI66, TYRO3_DANRE;  Q06418, TYRO3_HUMAN;  P55144, TYRO3_MOUSE;  
P55146, TYRO3_RAT;  Q8QFP9, TYRO3_XENLA;  A0JM20, TYRO3_XENTR;  
P30530, UFO_HUMAN;  Q00993, UFO_MOUSE;  O61460, VAB1_CAEEL;  
Q8QHL3, VGFR1_CHICK;  P17948, VGFR1_HUMAN;  P35969, VGFR1_MOUSE;  
P53767, VGFR1_RAT;  P52583, VGFR2_COTJA;  Q5GIT4, VGFR2_DANRE;  
P35968, VGFR2_HUMAN;  P35918, VGFR2_MOUSE;  O08775, VGFR2_RAT;  
P79701, VGFR3_COTCO;  Q5MD89, VGFR3_DANRE;  P35916, VGFR3_HUMAN;  
P35917, VGFR3_MOUSE;  Q91ZT1, VGFR3_RAT;  Q8AXB3, VGFR4_DANRE;  
P83097, WSCK_DROME;  P13388, XMRK_XIPMA;  Q9C823, Y1523_ARATH;  
O22938, Y2182_ARATH;  Q19238, YS3J_CAEEL;  

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