ID   2.7.11.10
DE   I-kappa-B kinase.
AN   CHUK.
AN   IKBKA.
AN   IKBKB.
AN   IKK.
AN   IKK-1.
AN   IKK-2.
AN   Inhibitor of NF-kappa-B kinase.
AN   TANK-binding kinase 1.
AN   TBK1.
CA   ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
CC   -!- Phosphorylates I-kappa-B proteins at specific serine residues, which
CC       marks them for destruction via the ubiquitination pathway.
CC   -!- Subsequent degradation of the I-kappa-B complex (IKK) activates
CC       NF-kappa-B, a translation factor that plays an important role in
CC       inflammation, immunity, cell proliferation and apoptosis.
CC   -!- If the serine residues are replaced by threonine residues,
CC       the activity of the enzyme is decreased considerably.
CC   -!- Formerly EC 2.7.1.37.
PR   PROSITE; PDOC00100;
DR   Q95KV1, IKKA_BOVIN ;  Q5ZJB4, IKKA_CHICK ;  Q4G3H4, IKKA_DANRE ;
DR   O15111, IKKA_HUMAN ;  Q60680, IKKA_MOUSE ;  Q6GM53, IKKA_XENLA ;
DR   Q28DZ1, IKKA_XENTR ;  Q95KV0, IKKB_BOVIN ;  Q9VEZ5, IKKB_DROME ;
DR   O14920, IKKB_HUMAN ;  O88351, IKKB_MOUSE ;  Q9QY78, IKKB_RAT   ;
DR   Q14164, IKKE_HUMAN ;  Q9R0T8, IKKE_MOUSE ;
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