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ENZYME entry: EC 2.7.11.12

Accepted Name
cGMP-dependent protein kinase.
Alternative Name(s)
3':5'-cyclic GMP-dependent protein kinase.
cGMP-dependent protein kinase I-beta.
Guanosine 3':5'-cyclic monophosphate-dependent protein kinase.
PKG.
PKG 1-alpha.
PKG 1-beta.
PKG II.
Reaction catalysed
ATP + a protein <=> ADP + a phosphoprotein
Comment(s)
  • cGMP is required to activate this enzyme.
  • The enzyme occurs as a dimer in higher eukaryotes.
  • The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites.
  • This domain catalyzes the phosphorylation by ATP to specific serine or threonine residues in protein substrates.
  • The enzyme also has two allosteric cGMP-binding sites (sites A and B).
  • Binding of cGMP causes a conformational change that is associated with activation of the kinase.
  • Formerly EC 2.7.1.37.
Cross-references
PROSITEPDOC00100
BRENDA2.7.11.12
EC2PDB2.7.11.12
ExplorEnz2.7.11.12
PRIAM enzyme-specific profiles2.7.11.12
KEGG Ligand Database for Enzyme Nomenclature2.7.11.12
IUBMB Enzyme Nomenclature2.7.11.12
IntEnz2.7.11.12
MEDLINEFind literature relating to 2.7.11.12
MetaCyc2.7.11.12
UniProtKB/Swiss-Prot
A8X6H1, EGL4_CAEBR;  O76360, EGL4_CAEEL;  P00516, KGP1_BOVIN;  
Q03042, KGP1_DROME;  Q13976, KGP1_HUMAN;  P0C605, KGP1_MOUSE;  
O77676, KGP1_RABIT;  Q03043, KGP24_DROME;  P32023, KGP25_DROME;  
Q13237, KGP2_HUMAN;  Q61410, KGP2_MOUSE;  Q64595, KGP2_RAT;  

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