ENZYME entry: EC 2.7.11.13

Accepted Name
Protein kinase C.
Alternative Name(s)
Calcium-dependent protein kinase C.
Calcium-independent protein kinase C.
Calcium/phospholipid dependent protein kinase.
CPKC.
NPKC.
PKC.
Reaction catalysed
ATP + a protein <=> ADP + a phosphoprotein
Comment(s)
  • A family of serine- and threonine-specific protein kinases that depend on lipids for activity.
  • They can be activated by calcium but have a requirement for the second messenger diacylglycerol.
  • Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways.
  • Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters.
  • Formerly EC 2.7.1.37.
Cross-references
PROSITEPDOC00100
BRENDA2.7.11.13
EC2PDB2.7.11.13
ExplorEnz2.7.11.13
PRIAM enzyme-specific profiles2.7.11.13
KEGG Ligand Database for Enzyme Nomenclature2.7.11.13
IUBMB Enzyme Nomenclature2.7.11.13
IntEnz2.7.11.13
MEDLINEFind literature relating to 2.7.11.13
MetaCyc2.7.11.13
UniProtKB/Swiss-Prot
A1Z9X0, APKC_DROME;  A8XWC4, DKF1_CAEBR;  Q9XUJ7, DKF1_CAEEL;  
A8XQD5, DKF2_CAEBR;  O45818, DKF2_CAEEL;  P34885, KPC1B_CAEEL;  
Q16974, KPC1_APLCA;  Q00078, KPC1_ASPNG;  P34722, KPC1_CAEEL;  
P43057, KPC1_CANAX;  O42632, KPC1_COCHE;  P05130, KPC1_DROME;  
Q99014, KPC1_HYPJE;  Q25378, KPC1_LYTPI;  P87253, KPC1_NEUCR;  
P24583, KPC1_YEAST;  Q16975, KPC2_APLCA;  P90980, KPC2_CAEEL;  
P13677, KPC2_DROME;  A8WUG4, KPC3_CAEBR;  Q19266, KPC3_CAEEL;  
P13678, KPC3_DROME;  P83099, KPC4_DROME;  P04409, KPCA_BOVIN;  
P17252, KPCA_HUMAN;  P20444, KPCA_MOUSE;  P10102, KPCA_RABIT;  
P05696, KPCA_RAT;  P05126, KPCB_BOVIN;  Q7SY24, KPCB_DANRE;  
P05771, KPCB_HUMAN;  P68404, KPCB_MOUSE;  P05772, KPCB_RABIT;  
P68403, KPCB_RAT;  Q7LZQ8, KPCB_XENLA;  A8KBH6, KPCB_XENTR;  
Q15139, KPCD1_HUMAN;  Q62101, KPCD1_MOUSE;  Q9WTQ1, KPCD1_RAT;  
Q9BZL6, KPCD2_HUMAN;  Q8BZ03, KPCD2_MOUSE;  Q5XIS9, KPCD2_RAT;  
O94806, KPCD3_HUMAN;  Q8K1Y2, KPCD3_MOUSE;  Q5PU49, KPCD_CANLF;  
Q05655, KPCD_HUMAN;  P28867, KPCD_MOUSE;  P09215, KPCD_RAT;  
Q02156, KPCE_HUMAN;  P16054, KPCE_MOUSE;  P10830, KPCE_RABIT;  
P09216, KPCE_RAT;  P05128, KPCG_BOVIN;  P05129, KPCG_HUMAN;  
Q4R4U2, KPCG_MACFA;  P63318, KPCG_MOUSE;  P10829, KPCG_RABIT;  
P63319, KPCG_RAT;  Q90XF2, KPCI_DANRE;  P41743, KPCI_HUMAN;  
Q62074, KPCI_MOUSE;  Q5R4K9, KPCI_PONAB;  F1M7Y5, KPCI_RAT;  
P24723, KPCL_HUMAN;  P23298, KPCL_MOUSE;  Q64617, KPCL_RAT;  
Q04759, KPCT_HUMAN;  Q02111, KPCT_MOUSE;  Q9WTQ0, KPCT_RAT;  
Q05513, KPCZ_HUMAN;  Q02956, KPCZ_MOUSE;  O19111, KPCZ_RABIT;  
P09217, KPCZ_RAT;  P36582, PCK1_SCHPO;  P36583, PCK2_SCHPO;  
A1A4I4, PKN1_BOVIN;  Q16512, PKN1_HUMAN;  P70268, PKN1_MOUSE;  
Q63433, PKN1_RAT;  A7MBL8, PKN2_DANRE;  Q16513, PKN2_HUMAN;  
Q8BWW9, PKN2_MOUSE;  O08874, PKN2_RAT;  Q6P5Z2, PKN3_HUMAN;  
Q8K045, PKN3_MOUSE;  A1Z7T0, PKN_DROME;  

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